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Mutations in the HIV-1 3'-Polypurine Tract Can Confer Dolutegravir Resistance.

作者信息

Dekker José G, Klaver Bep, Berkhout Ben, Das Atze T

机构信息

Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdamgrid.7177.6, Amsterdam, The Netherlands.

出版信息

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0102721. doi: 10.1128/AAC.01027-21. Epub 2021 Oct 11.

DOI:10.1128/AAC.01027-21
PMID:34633840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8765316/
Abstract
摘要

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Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance.HIV-1 3'-多聚嘌呤序列突变与整合酶链转移抑制剂耐药性
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02432-20.
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Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function.逆转表观遗传沉默可使 HIV-1 在没有整合酶功能的情况下进行稳健复制。
mBio. 2020 Jun 2;11(3):e01038-20. doi: 10.1128/mBio.01038-20.
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Authentication Analysis of MT-4 Cells Distributed by the National Institutes of Health AIDS Reagent Program.美国国立卫生研究院艾滋病试剂计划分发的 MT-4 细胞的鉴定分析。
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6
Reply to Das and Berkhout, "How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir".对达斯和伯克霍特的回复：“HIV-1 RNA基因组中的多聚嘌呤序列变化如何导致对整合酶抑制剂多替拉韦产生耐药性”
mBio. 2018 May 29;9(3):e00623-18. doi: 10.1128/mBio.00623-18.
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How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir.HIV-1 RNA基因组中的多嘌呤序列变化如何导致对整合酶抑制剂多替拉韦产生耐药性。
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HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.多替拉韦维持治疗失败的患者中 HIV-1 耐药性的动态变化。
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