Lamberts S W, Angement R, van der Heijden A, Wladimiroff J W, Hackeng W H, de Jong F H
Department of Medicine, Erasmus University, Rotterdam, The Netherlands.
Horm Res. 1987;27(4):195-9. doi: 10.1159/000180819.
The course of plasma beta-endorphin/beta-lipotropin, cortisol and prolactin (PRL) levels was followed from 0.5 till 5 h after normal delivery in 13 healthy women. Six subjects who did not want to breast-feed their child received 2.5 mg bromocriptine orally 1 h after delivery. After 3 h the effect of the intravenous administration of 200 micrograms thyrotropin-releasing hormone (TRH) was also measured. Elevated plasma beta-endorphin and cortisol levels decreased after delivery in a (log) linear fashion which was not influenced by bromocriptine. TRH elicited a significant short-lived identical increase in plasma beta-endorphin/beta-lipotropin concentrations in the control and the bromocriptine-treated subjects. TRH similarly delayed the rapid decline in plasma cortisol levels in both groups of women. Basal and TRH-induced PRL levels were rapidly suppressed by bromocriptine. These studies show the presence of a paradoxical increase of beta-endorphin/beta-lipotropin and cortisol levels in response to TRH occurring shortly after delivery in normal women. This response cannot be mediated by the placenta. The absence of an inhibiting effect of bromocriptine on basal and TRH-induced beta-endorphin and cortisol release does not lend support to the hypothesis of the presence of a functionally active intermediate pituitary lobe in man early in puerperium.
对13名健康女性正常分娩后0.5至5小时内血浆β-内啡肽/β-促脂素、皮质醇和催乳素（PRL）水平的变化过程进行了跟踪研究。6名不想母乳喂养孩子的受试者在分娩后1小时口服2.5毫克溴隐亭。3小时后，还测量了静脉注射200微克促甲状腺激素释放激素（TRH）的效果。分娩后，血浆β-内啡肽和皮质醇水平升高呈（对数）线性下降，不受溴隐亭影响。TRH在对照组和溴隐亭治疗组受试者中引起血浆β-内啡肽/β-促脂素浓度显著且短暂的相同升高。TRH同样延迟了两组女性血浆皮质醇水平的快速下降。溴隐亭迅速抑制了基础和TRH诱导的PRL水平。这些研究表明，正常女性分娩后不久，TRH会引起β-内啡肽/β-促脂素和皮质醇水平出现矛盾性升高。这种反应不能由胎盘介导。溴隐亭对基础和TRH诱导的β-内啡肽和皮质醇释放没有抑制作用，这并不支持产后早期人体存在功能活跃的垂体中叶这一假说。
