利用β-硅效应实现受供体卡宾调控的区域和立体选择性铑（II）催化 C-H 功能化反应，供体卡宾由 1-磺酰基-1,2,3-三唑衍生而来。
Harnessing the β-Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C-H Functionalization by Donor/Acceptor Carbenes Derived from 1-Sulfonyl-1,2,3-triazoles.
机构信息
Department of Chemistry , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States.
出版信息
Org Lett. 2018 Apr 20;20(8):2168-2171. doi: 10.1021/acs.orglett.8b00427. Epub 2018 Apr 11.
Abstract
The regioselective and enantioselective intermolecular sp C-H functionalization of silicon-substituted alkanes was accomplished using Rh( S-NTTL) with readily available 1-sulfonyl-1,2,3-triazoles as carbene precursors. These reactions generate a diverse array of stereodefined substituted silaalkanes.
摘要
使用 Rh( S-NTTL)和易得的 1-磺酰基-1,2,3-三唑作为卡宾前体，实现了硅取代烷烃的区域选择性和对映选择性的分子间 sp3 C-H 官能化。这些反应生成了一系列具有不同立体定义的取代硅烷。
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