Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13054-7. doi: 10.1002/anie.201207820. Epub 2012 Nov 19.
Room for expansion: an efficient, regioselective, and convergent method for the ring expansion and rearrangement of 1-sulfonyl-1,2,3-triazoles under rhodium(II)-catalyzed conditions is described. These denitrogenative reactions form substituted enaminone and olefin-based products. The enaminone products can be further functionalized to give various heterocycles and ketone derivatives, thus rendering the sulfonyl triazole traceless.
在铑(II)催化条件下,描述了一种高效、区域选择性和收敛的 1-磺酰基-1,2,3-三唑的环扩张和重排方法。这些脱氮反应形成取代烯胺酮和烯烃基产物。烯胺酮产物可以进一步官能化,得到各种杂环和酮衍生物,从而使磺酰基三唑无痕。