Neven A, Kool N, Bonebakker A E, Mulder C L
Tijdschr Psychiatr. 2018;60(4):231-240.
Dual diagnosis (substance use disorder combined with a comorbid mental illness) is a common problem. One of the methods to treat this is integrated dual diagnosis treatment (IDDT). IDDT consists of the simultaneous, integrated application of different treatment components. Their efficacy, however, has only been studied separately. As a result, the effectiveness of the IDDT program as a whole remains unclear.
To evaluate the scientific evidence relevant to the effectiveness of IDDT in dual diagnosis patients.
A systematic literature review using MEDLINE, Embase and PsycINFO (Prisma guideline).
Six studies were found: a randomised controlled study (RCT), two non-randomised controlled studies, and three uncontrolled pre-post studies . There was a notably large diversity in outcome measures. The results differed significantly, including some studies concluding a significant (additional) effect, while others concluded that there was no indication of a significant effect of IDDT.
In clinical practice, IDDT is recommended and chosen frequently as the treatment for patients with dual diagnosis. However, it is remarkable how limited and unthorough the research is pertaining to the effects of the full IDDT program on dual diagnosis.
双重诊断（物质使用障碍合并共病性精神疾病）是一个常见问题。治疗此问题的方法之一是综合双重诊断治疗（IDDT）。IDDT包括同时、综合应用不同的治疗成分。然而，它们的疗效仅分别进行了研究。因此，整个IDDT项目的有效性仍不明确。
评估与IDDT对双重诊断患者有效性相关的科学证据。
使用MEDLINE、Embase和PsycINFO进行系统文献综述（遵循Prisma指南）。
共找到六项研究：一项随机对照试验（RCT）、两项非随机对照研究和三项非对照前后对照研究。结局指标存在显著差异。结果差异显著，包括一些研究得出显著（额外）效果的结论，而其他研究则得出没有迹象表明IDDT有显著效果的结论。
在临床实践中，IDDT经常被推荐并选作双重诊断患者的治疗方法。然而，令人瞩目的是，关于整个IDDT项目对双重诊断影响的研究非常有限且不全面。
