Husby G, Williams R C, Tung K S, Smith F E, Cronin R J, Sletten K, Westermark P
Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87131.
J Lab Clin Med. 1988 Mar;111(3):307-14.
Identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis were the subjects of a study done with mixed leukocyte culture, anti-idiotypic antisera against serum and urinary M component from the amyloid-affected twin, and in vitro estimations of M-component idiotype synthesis by peripheral blood mononuclear cells. Immunohistochemical analysis of renal amyloid deposits in the affected twin showed AL amyloid of the lambda-II variable region subgroup. M-component idiotypes were confined only to the twin with serum and urine M components.
一对同卵双胞胎，其中一人患有青少年类风湿性关节炎，同时患有单克隆丙种球蛋白病和淀粉样变性，另一人仅患青少年类风湿性关节炎，以此为研究对象进行了混合白细胞培养、针对淀粉样变性双胞胎血清和尿液M成分的抗独特型抗血清以及外周血单核细胞对M成分独特型合成的体外评估。对患病双胞胎肾脏淀粉样沉积物的免疫组织化学分析显示为λ-II可变区亚组的AL淀粉样蛋白。M成分独特型仅局限于有血清和尿液M成分的双胞胎。
