Rouveix B, Chau F
Département de Pharmacologie Clinique, INSERM U.13, Hôpital Claude Bernard, Paris.
Pathol Biol (Paris). 1987 Dec;35(10 Pt 2):1450-3.
The in vitro effect of various cephalosporins on T lymphocyte functions was studied. These antibiotics directly stimulated lymphokine production and significantly suppressed mitogen-stimulated lymphocyte transformation responses. Penicillin had no effect. Suppression of blastogenesis could be mediated through suppressor cell enhancement as indicated by: i) the significant suppressed lymphocyte transformation observed while using the dialyzed supernatant of cephalosporin-stimulated and cultured lymphocytes, ii) the enhanced blastogenesis, commonly ascribed to suppressor cell depletion, blunted by pre-incubation with cephalosporins, iii) the suppressed blastogenesis of allogenic responder cells in MLR by cephalosporin pre-incubated, mitomycin treated cells. An indirect effect through PgE2 release by macrophages cannot ruled out. The enhancement of suppressor activity by most of the cephalosporins might explain the smaller incidence of late hypersensitivity reactions observed with these antibiotics compared with penicillins.
研究了各种头孢菌素对T淋巴细胞功能的体外作用。这些抗生素直接刺激淋巴因子的产生，并显著抑制有丝分裂原刺激的淋巴细胞转化反应。青霉素无此作用。母细胞生成的抑制可能是通过抑制细胞增强介导的，表现为：i）使用头孢菌素刺激并培养的淋巴细胞的透析上清液时观察到显著抑制的淋巴细胞转化；ii）通常归因于抑制细胞耗竭的母细胞生成增强，因预先用头孢菌素孵育而减弱；iii）经头孢菌素预先孵育、丝裂霉素处理的细胞在混合淋巴细胞反应中对同种异体反应细胞母细胞生成的抑制。不能排除通过巨噬细胞释放PgE2产生的间接作用。大多数头孢菌素对抑制活性的增强作用可能解释了与青霉素相比，使用这些抗生素观察到的迟发型超敏反应发生率较低的原因。
