Fenichel P, Guedj A M, Verdino P, Brucker F, Strulo S, Mehouas C, Harter M
Centre de lutte contre l'infertilité, CHU de Nice.
Presse Med. 1988 Jan 23;17(2):61-4.
Hypothalamic amenorrhoea is characterized by deficiency of the pulsatile secretion of the gonadotropin-releasing hormone. In 18 patients with hypogonadotropic hypogonadism a precise topographical diagnosis could be made by pulsatile administration of this hormone using a portable pump, after failure of the simple gonadotropin-releasing hormone test (100 micrograms intravenously). In women wishing to become pregnant, this treatment proved valuable to induce ovulation, being remarkably effective (17 pregnancies in 20 women (85 p. 100) and 2.2 cycles/pregnancy), easy to perform, and safe, as well as less expensive and with less risk of hyperstimulation and multiple pregnancies than the conventional treatment with gonadotropins.
下丘脑性闭经的特征是促性腺激素释放激素脉冲分泌不足。在18例低促性腺激素性性腺功能减退患者中，在简单的促性腺激素释放激素试验（静脉注射100微克）失败后，使用便携式泵脉冲式给药该激素，可做出精确的定位诊断。对于希望怀孕的女性，这种治疗方法被证明对诱导排卵很有价值，效果显著（20名女性中有17例怀孕（85%），每次怀孕平均2.2个周期），操作简便、安全，而且与传统的促性腺激素治疗相比，费用更低，过度刺激和多胎妊娠的风险更小。
