Fleck C
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, G.D.R.
Physiol Bohemoslov. 1987;36(6):511-7.
Twenty hours after unilateral nephrectomy (uNX) the PAH excretion of uninephrectomized rats reaches about 80% of the controls. Immediately after removal of one kidney the parenchyma loss can be compensated by an intensification of glomerular filtration. Thereafter the active tubular secretion capacity raises. 24 h after uNX, a significant increase of renal mass could be measured. The specific PAH accumulation capacity per 1 g renal cortical tissue increases significantly 96 h after uNX if the animals had been pretreated with cyclopenthiazide before the operation. Administration of azauracil or fluoruracil or neomycin causes a dose-dependent reduction of PAH elimination in sham operated as well as in uNX-rats. The effect of stimulation by cyclopenthiazide, also occurring after uNX could be reduced significantly by the inhibitors. The relative extent of compensation (80 +/- 10%) was not influenced by the inhibitors of protein synthesis. The compensation after uNX and the stimulation of renal tubular function are mediated by different mechanisms.
单侧肾切除（uNX）20小时后，单侧肾切除大鼠的对氨基马尿酸（PAH）排泄量达到对照组的约80%。切除一侧肾脏后，肾实质损失可通过肾小球滤过增强得到代偿。此后，肾小管主动分泌能力提高。uNX术后24小时，可测量到肾脏重量显著增加。如果动物在手术前用环戊噻嗪预处理，uNX术后96小时，每1克肾皮质组织的PAH蓄积能力显著增加。给予氮尿嘧啶、氟尿嘧啶或新霉素会导致假手术大鼠和uNX大鼠的PAH清除率呈剂量依赖性降低。蛋白质合成抑制剂可显著降低环戊噻嗪刺激的作用，uNX后也会出现这种刺激作用。补偿的相对程度（80±10%）不受蛋白质合成抑制剂的影响。uNX后的补偿和肾小管功能的刺激是由不同机制介导的。
