Bräunlich H
Exp Clin Endocrinol. 1984 May;83(3):243-50. doi: 10.1055/s-0029-1210336.
In immature rats, renal excretion of p-aminohippurate (PAH) can be increased by daily pretreatment with triiodothyronine (T3) or tetraiodothyronine (T4) beginning on the 2nd day after birth (10 micrograms/100 g b.wt. i.p.). The increase of PAH excretion is nearly of the same extent, if 5-, 10-, 20-, 30-, 50-, and 105-day-old rats were pretreated with thyroid hormones (10 micrograms/100 g b.wt. i.p., 3 days, once daily). There is no strongly dose dependent renal effect of T3 and T4, respectively. The time course of stimulation of renal PAH excretion was also characterized in rats of different ages. Simultaneous pretreatment of young and adult rats with cyclopenthiazide and T3 is not distinctly more effective as both components given alone. Particularly the low degree of stimulation in young rats receiving cyclopenthiazide cannot be pronounced by additional T3 administration. Inhibitors of protein biosynthesis (azauracil, neomycin) can antagonize the stimulation of renal p-amino-hippurate excretion in rats receiving T3. The presented data indicate that T3 is effective in young rats. Furthermore, T4 can be converted to T3 in young rats, too. The importance of an intact protein synthesis seems to be a prerequisite to stimulate the kidney function by T3 pretreatment.
在未成熟大鼠中，从出生后第2天开始每天腹腔注射三碘甲状腺原氨酸（T3）或四碘甲状腺原氨酸（T4）（10微克/100克体重）进行预处理，可增加对氨基马尿酸（PAH）的肾排泄。如果对5日龄、10日龄、20日龄、30日龄、50日龄和105日龄的大鼠用甲状腺激素（10微克/100克体重，腹腔注射，连续3天，每天1次）进行预处理，PAH排泄的增加幅度几乎相同。T3和T4分别对肾脏没有明显的剂量依赖性作用。还对不同年龄大鼠肾脏PAH排泄刺激的时间进程进行了研究。同时用环戊噻嗪和T3对幼鼠和成年鼠进行预处理，并不比单独给予这两种成分更有效。特别是，接受环戊噻嗪的幼鼠中较低程度的刺激，不会因额外给予T3而明显增强。蛋白质生物合成抑制剂（氮尿嘧啶、新霉素）可拮抗接受T3的大鼠肾脏对氨基马尿酸排泄的刺激作用。所呈现的数据表明T3对幼鼠有效。此外，T4在幼鼠中也可转化为T3。完整的蛋白质合成似乎是通过T3预处理刺激肾功能的一个先决条件。
