一种基于碳氮纳米带的新型“关-开”荧光探针用于检测柠檬酸根阴离子和活细胞成像。
A Novel "Off-On" Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging.
机构信息
Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
College of Geography and Biological Information, Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
出版信息
Sensors (Basel). 2018 Apr 11;18(4):1163. doi: 10.3390/s18041163.
A novel fluorescent "off-on" probe based on carbon nitride (C₃N₄) nanoribbons was developed for citrate anion (C₆H₅O₇) detection. The fluorescence of C₃N₄ nanoribbons can be quenched by Cu and then recovered by the addition of C₆H₅O₇, because the chelation between C₆H₅O₇ and Cu blocks the electron transfer between Cu and C₃N₄ nanoribbons. The turn-on fluorescent sensor using this fluorescent "off-on" probe can detect C₆H₅O₇ rapidly and selectively, showing a wide detection linear range (1~400 μM) and a low detection limit (0.78 μM) in aqueous solutions. Importantly, this C₃N₄ nanoribbon-based "off-on" probe exhibits good biocompatibility and can be used as fluorescent visualizer for exogenous C₆H₅O₇ in HeLa cells.
一种基于氮化碳（C₃N₄）纳米带的新型荧光“关-开”探针被开发用于检测柠檬酸根阴离子（C₆H₅O₇）。C₃N₄纳米带的荧光可以被 Cu 猝灭，然后通过添加 C₆H₅O₇恢复，因为 C₆H₅O₇与 Cu 的螯合阻止了 Cu 和 C₃N₄纳米带之间的电子转移。使用这种荧光“关-开”探针的开荧光传感器可以快速和选择性地检测 C₆H₅O₇，在水溶液中显示出宽的检测线性范围（1~400 μM）和低的检测限（0.78 μM）。重要的是，这种基于 C₃N₄纳米带的“关-开”探针具有良好的生物相容性，可作为 HeLa 细胞中外源性 C₆H₅O₇的荧光可视化剂。
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