Laboratory of Molecular Oncology, Lungen- und Thoraxonkologie Zentrum, University Hospital Zurich, Sternwartstrasse 14, 8091 Zürich, Switzerland.
Functional Genomics Center Zurich, ETH Zurich and University of Zurich, 8057 Zurich, Switzerland.
Int J Mol Sci. 2018 Apr 11;19(4):1163. doi: 10.3390/ijms19041163.
Mesothelioma is an aggressive, rapidly fatal cancer and a better understanding of its molecular heterogeneity may help with making more efficient therapeutic strategies. Non-coding RNAs represent a larger part of the transcriptome but their contribution to diseases is not fully understood yet. We used recently obtained RNA-seq data from asbestos-exposed mice and performed data mining of publicly available datasets in order to evaluate how non-coding RNA contribute to mesothelioma heterogeneity. Nine non-coding RNAs are specifically elevated in mesothelioma tumors and contribute to human mesothelioma heterogeneity. Because some of them have known oncogenic properties, this study supports the concept of non-coding RNAs as cancer progenitor genes.
间皮瘤是一种侵袭性的、快速致命的癌症，更好地了解其分子异质性可能有助于制定更有效的治疗策略。非编码 RNA 占转录组的比例更大，但它们对疾病的贡献尚未完全了解。我们使用最近从暴露于石棉的小鼠中获得的 RNA-seq 数据，并对公开可用的数据集进行数据挖掘，以评估非编码 RNA 如何促进间皮瘤异质性。有 9 种非编码 RNA 在间皮瘤肿瘤中特异性升高，并导致人类间皮瘤异质性。由于其中一些具有已知的致癌特性，因此这项研究支持非编码 RNA 作为癌症祖基因的概念。
