Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Trends Cell Biol. 2018 Apr;28(4):287-301. doi: 10.1016/j.tcb.2017.11.008. Epub 2017 Dec 20.
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial layer of cancer cell regulation. lncRNAs are aberrantly expressed in a broad spectrum of cancers, and they play key roles in promoting and maintaining tumor initiation and progression, demonstrating their clinical potential as biomarkers and therapeutic targets. Recent discoveries have revealed that lncRNAs act as key signal transduction mediators in cancer signaling pathways by interacting with proteins, RNA, and lipids. Here, we review the mechanisms by which lncRNAs regulate cellular responses to extracellular signals and discuss their clinical potential as diagnostic indicators, stratification markers, and therapeutic targets of combinatorial treatments.
长链非编码 RNA（lncRNAs）是由人类基因组中一个广阔但尚未深入研究的区域编码的，它们可能是癌症缺失的驱动因素，最近作为癌细胞调控的一个潜在关键层受到关注。lncRNAs 在广泛的癌症中表达异常，它们在促进和维持肿瘤发生和进展中发挥关键作用，显示出它们作为生物标志物和治疗靶点的临床潜力。最近的发现表明，lncRNAs 通过与蛋白质、RNA 和脂质相互作用，作为癌症信号通路中关键的信号转导介质发挥作用。在这里，我们综述了 lncRNAs 调节细胞对外界信号反应的机制，并讨论了它们作为诊断指标、分层标记物以及组合治疗治疗靶点的临床潜力。
