Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Department of Public Health and Preventive Medicine, St. George's University, Grenada, West Indies.
PLoS One. 2018 Apr 11;13(4):e0194560. doi: 10.1371/journal.pone.0194560. eCollection 2018.
Pulmonary rehabilitation, including aerobic exercise and strength training, improves function, such as spirometric indices, in lung disease. However, we found spirometry did not correlate with physical activity (PA) in healthy adolescents (Smith ERJ: 42(4), 2016). To address whether muscle strength did, we measured these adolescents' handgrip strength and correlated it with spirometry.
In 1846 non-smoking, non-asthmatic Germans (age 15.2 years, 47% male), we modeled spirometric indices as functions of handgrip strength by linear regression in each sex, corrected for factors including age, height, and lean body mass.
Handgrip averaged 35.4 (SD 7.3) kg in boys, 26.6 (4.2) in girls. Spirometric volumes and flows increased linearly with handgrip. In boys each kg handgrip was associated with about 28 mL greater FEV1 and FVC; 60 mL/sec faster PEF; and 38 mL/sec faster FEF2575. Effects were 10-30% smaller in girls (all p<0.0001) and stable when Z-scores for spirometry and grip were modeled, after further correction for environment and/or other exposures, and consistent across stages of puberty.
Grip strength was associated with spirometry in a cohort of healthy adolescents whose PA was not. Thus, research into PA's relationship with lung function should consider strength as well as total PA. Strength training may benefit healthy lungs; interventions are needed to prove causality.
肺康复，包括有氧运动和力量训练，可以改善肺部疾病患者的功能，如肺活量指数。然而，我们发现肺康复并不能改善健康青少年的体力活动（PA）。为了解决肌肉力量是否与肺康复相关的问题，我们测量了这些青少年的握力，并将其与肺功能相关联。
在 1846 名不吸烟、非哮喘的德国青少年（年龄 15.2 岁，47%为男性）中，我们通过线性回归模型，分别在男女性别中，将肺活量指数作为握力的函数进行建模，模型校正因素包括年龄、身高和瘦体重。
男孩的平均握力为 35.4（SD 7.3）kg，女孩为 26.6（4.2）kg。肺活量和流量与握力呈线性增加。在男孩中，每公斤握力与 FEV1 和 FVC 增加约 28ml；PEF 增加 60ml/sec；FEF2575 增加 38ml/sec。在女孩中，这些效果小 10-30%（均 P<0.0001），并且在进一步校正环境和/或其他暴露因素后，以及在青春期的各个阶段，握力与肺功能之间的关系仍然稳定。
在一组 PA 未改变的健康青少年中，握力与肺功能相关。因此，研究 PA 与肺功能的关系时，应该考虑到力量和总 PA。力量训练可能对健康的肺部有益；需要干预措施来证明因果关系。
