Institute of Epidemiology 1, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians University, Munich, Germany.
Department of Paediatrics, Marien-Hospital Wesel, Wesel, Germany.
Eur Respir J. 2016 Aug;48(2):428-40. doi: 10.1183/13993003.01408-2015. Epub 2016 Mar 23.
In lung disease, physical activity improves lung function and reduces morbidity. However, healthy populations are not well studied. We estimate the relationship between spirometric indices and accelerometric physical activity in lung-healthy adolescents.895 nonsmoking German adolescents without chronic lung disease (45% male, mean±sd age 15.2±0.26 years) from the GINIplus and LISAplus cohorts completed questionnaires, spirometry, 7-day accelerometry and an activity diary. Physical activity was measured as minutes, quintiles and regularity of daily moderate, vigorous and moderate-to-vigorous physical activity (MVPA), participation in sport and active commuting to school. Primary outcomes were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory flow at 25-75% of FVC; they were separately correlated with physical activity and adjusted for confounders of respiratory function, including early-life exposures.Adolescents averaged 40 min MVPA per day, typical for European youth. 79% participated in sports and 51% commuted actively. An association was suggested between 3% higher FVC (∼100 mL) and either extreme MVPA quintile or percentage of days with >30 min MVPA (p<0.05). However, after Bonferroni correction all associations between spirometry, active lifestyle and physical activity were nonsignificant.Spirometric indices were not significantly associated with active lifestyle or measures of activity in lung-healthy adolescents after adjustment for confounding and multiple-comparison artefacts.
在肺部疾病中，身体活动可改善肺功能并降低发病率。然而，对于健康人群的研究并不充分。我们评估了肺健康青少年的肺活量计指数与加速度计身体活动之间的关系。895 名无慢性肺部疾病的德国非吸烟青少年（男性占 45%，平均年龄±标准差为 15.2±0.26 岁）来自 GINIplus 和 LISAplus 队列，他们完成了问卷调查、肺量计检查、7 天加速度计和活动日记。身体活动以分钟、五分位数和日常中、高强度和中高强度体力活动（MVPA）的规律性、参与运动和积极上学通勤来衡量。主要结局指标为 1 秒用力呼气量（FEV1）、用力肺活量（FVC）、FEV1/FVC 和 FVC 用力呼出 25-75%的流量（FEF25-75）；它们分别与身体活动相关，并针对呼吸功能的混杂因素进行了调整，包括生命早期的暴露。青少年平均每天进行 40 分钟的 MVPA，这在欧洲青少年中是典型的。79%的人参加运动，51%的人积极上学通勤。提示 FVC 增加 3%（约 100ml）与极端 MVPA 五分位数或大于 30 分钟 MVPA 的天数百分比之间存在关联（p<0.05）。然而，在 Bonferroni 校正后，肺活量计、积极生活方式和身体活动之间的所有关联在调整混杂因素和多重比较影响后均无统计学意义。在调整混杂因素和多重比较影响后，肺活量计指数与肺健康青少年的积极生活方式或活动测量值之间没有显著关联。
