World Health Organization Collaborating Center for Vaccine Research, Evaluation and Training on Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA.
World Health Organization Collaborating Center for Vaccine Research, Evaluation and Training on Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, USA.
Curr Opin Virol. 2018 Apr;29:72-78. doi: 10.1016/j.coviro.2018.03.005. Epub 2018 Apr 9.
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and transmission, clinical manifestations, immunological responses, and treatment regimens. A number of animal models have been investigated but, to date, none recapitulate all the clinical manifestations seen in humans. Vaccine development is at an early discovery phase.
发热伴血小板减少综合征（SFTS）是一种由布尼亚病毒科白蛉病毒属的发热伴血小板减少综合征病毒（SFTSV）引起的新发蜱媒传染病。该病毒于 2009 年在中国中部地区被发现，此后在日本和韩国也被发现。病毒的分子生物学研究取得了重大进展，并已用于开发诊断检测和试剂。在流行病学、维持和传播、临床表现、免疫反应和治疗方案方面的进展较少。已经研究了一些动物模型，但迄今为止，没有一种模型能重现人类所有的临床表现。疫苗的开发处于早期发现阶段。
