• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肺癌患者中的人类免疫缺陷病毒感染与死亡风险：一项系统评价和荟萃分析。

Human immunodeficiency virus infection and mortality risk among lung cancer patients: A systematic review and meta-analysis.

作者信息

Wang Yue-Hua, Shen Xiang-Di

机构信息

Department of Respiration, Jinhua People's Hospital, Jinhua Faculty of Basic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.

出版信息

Medicine (Baltimore). 2018 Apr;97(15):e0361. doi: 10.1097/MD.0000000000010361.

DOI:10.1097/MD.0000000000010361
PMID:29642182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5908612/
Abstract

BACKGROUND

Previous studies have suggested that patients with human immunodeficiency virus (HIV) infection are at higher risk of lung cancer, but the impact of HIV infection on the risk of mortality among lung cancer patients is still unclear. We conducted a systematic review and meta-analysis to clarify the association between HIV infection and mortality risk among lung cancer patients.

METHODS

PubMed and Embase databases were searched to identify studies assessing the association between HIV infection and mortality risk among lung cancer patients. Only studies reporting adjusted relative risk (RR) of mortality among lung cancer patients with HIV infection were included. Meta-analysis of random-effect model was utilized to calculate the pooled RR with 95% confidence interval (CI).

RESULTS

Twelve cohort studies were finally included. Compared with lung cancer patients without HIV infection, the pooled RR of mortality among lung cancer patients with HIV infection was 1.48 (95% CI, 1.22-1.78, P < .001; I = 88.6%). After excluding 2 studies with low quality, HIV infection was still significantly associated with an elevated risk of mortality among lung cancer patients (RR = 1.51, 95% CI, 1.25-1.82, P < .001; I = 89.8%). Sensitivity analysis showed that the statistical significance of the pooled RR was not changed by excluding any one study.

CONCLUSION

The outcomes from the meta-analysis provide strong evidence for the elevated risk of mortality among lung cancer patients with HIV infection, and HIV infection is an important prognostic factor in lung cancer patients.

摘要

背景

既往研究提示，人类免疫缺陷病毒（HIV）感染患者患肺癌的风险更高，但HIV感染对肺癌患者死亡风险的影响仍不明确。我们进行了一项系统评价和荟萃分析，以阐明HIV感染与肺癌患者死亡风险之间的关联。

方法

检索PubMed和Embase数据库，以识别评估HIV感染与肺癌患者死亡风险之间关联的研究。仅纳入报告了HIV感染的肺癌患者死亡校正相对风险（RR）的研究。采用随机效应模型进行荟萃分析，计算合并RR及95%置信区间（CI）。

结果

最终纳入12项队列研究。与未感染HIV的肺癌患者相比，感染HIV的肺癌患者死亡合并RR为1.48（95%CI，1.22 - 1.78，P<0.001；I=88.6%）。排除2项低质量研究后，HIV感染仍与肺癌患者死亡风险升高显著相关（RR=1.51，95%CI，1.25 - 1.82，P<0.001；I=89.8%）。敏感性分析表明，排除任何一项研究，合并RR的统计学意义均未改变。

结论

荟萃分析结果为感染HIV的肺癌患者死亡风险升高提供了有力证据，HIV感染是肺癌患者的一个重要预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/4a11e554b7a6/medi-97-e0361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/3b2d603acc55/medi-97-e0361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/1f0d52ce7af7/medi-97-e0361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/9f67bd6f4e61/medi-97-e0361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/e64c072095c8/medi-97-e0361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/4a11e554b7a6/medi-97-e0361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/3b2d603acc55/medi-97-e0361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/1f0d52ce7af7/medi-97-e0361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/9f67bd6f4e61/medi-97-e0361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/e64c072095c8/medi-97-e0361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff7d/5908612/4a11e554b7a6/medi-97-e0361-g006.jpg

相似文献

1
Human immunodeficiency virus infection and mortality risk among lung cancer patients: A systematic review and meta-analysis.肺癌患者中的人类免疫缺陷病毒感染与死亡风险：一项系统评价和荟萃分析。
Medicine (Baltimore). 2018 Apr;97(15):e0361. doi: 10.1097/MD.0000000000010361.
2
3
ABO blood groups and risk of human immunodeficiency virus infection: A systematic review and meta-analysis.ABO 血型与人类免疫缺陷病毒感染风险：系统评价和荟萃分析。
Rev Med Virol. 2022 May;32(3):e2298. doi: 10.1002/rmv.2298. Epub 2021 Sep 30.
4
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.用于治疗符合抗逆转录病毒治疗条件的孕妇艾滋病毒感染的抗逆转录病毒疗法。
Cochrane Database Syst Rev. 2010 Mar 17(3):CD008440. doi: 10.1002/14651858.CD008440.
5
The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis.孕产妇感染艾滋病毒与围产期结局之间的关联：文献系统综述与荟萃分析
Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. doi: 10.1111/j.1471-0528.1998.tb10227.x.
6
[A meta-analysis of HIV seroprevalence in pregnant women with syphilis and the impact of syphilis infection on mother-to-child HIV transmission].[梅毒感染孕妇的HIV血清流行率及梅毒感染对母婴HIV传播影响的荟萃分析]
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Nov 6;50(11):1001-1007. doi: 10.3760/cma.j.issn.0253-9624.2016.11.015.
7
The effectiveness of home-based HIV counseling and testing on reducing stigma and risky sexual behavior among adults and adolescents: A systematic review and meta-analyses.基于家庭的艾滋病毒咨询和检测对减少成年人及青少年耻辱感和危险性行为的有效性：一项系统评价和荟萃分析。
JBI Database System Rev Implement Rep. 2015 Jul 17;13(6):318-72. doi: 10.11124/jbisrir-2015-2235.
8
Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis.撒哈拉以南非洲地区男性包皮环切术与HIV感染风险：一项系统评价与荟萃分析。
AIDS. 2000 Oct 20;14(15):2361-70. doi: 10.1097/00002030-200010200-00018.
9
Male circumcision for the prevention of human immunodeficiency virus (HIV) acquisition: a meta-analysis.男性割礼预防人类免疫缺陷病毒（HIV）感染：荟萃分析。
BJU Int. 2018 Apr;121(4):515-526. doi: 10.1111/bju.14102. Epub 2018 Jan 29.
10
Risk factors for mortality among lung cancer patients with covid-19 infection: A systematic review and meta-analysis.新冠肺炎合并肺癌患者死亡的危险因素：系统评价和荟萃分析。
PLoS One. 2023 Sep 8;18(9):e0291178. doi: 10.1371/journal.pone.0291178. eCollection 2023.

引用本文的文献

1
HIV-associated lung disease.HIV 相关肺部疾病。
Nat Rev Dis Primers. 2023 Jul 27;9(1):39. doi: 10.1038/s41572-023-00450-5.
2
HIV-related lung cancer in Uganda: a cohort study.乌干达的艾滋病相关肺癌：一项队列研究。
Infect Agent Cancer. 2022 Jun 6;17(1):24. doi: 10.1186/s13027-022-00439-x.
3
Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection.增强的筛查方案对人类免疫缺陷病毒感染患者中非艾滋病性新生物检测的影响。

本文引用的文献

1
Occurrence of hepatocellular carcinoma in HIV/HCV co-infected patients treated with direct-acting antivirals.接受直接作用抗病毒药物治疗的HIV/HCV合并感染患者肝细胞癌的发生情况。
J Hepatol. 2017 Aug;67(2):415-417. doi: 10.1016/j.jhep.2017.03.032. Epub 2017 Apr 12.
2
Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy.HIV 状态与肛门鳞状细胞癌局部免疫反应的关系：对免疫治疗的启示。
JAMA Oncol. 2017 Jul 1;3(7):974-978. doi: 10.1001/jamaoncol.2017.0115.
3
T Cell Subpopulations in Healthy Elderly and Lung Cancer Patients: Insights from Cuban Studies.
Trials. 2021 Nov 27;22(1):851. doi: 10.1186/s13063-021-05777-6.
4
Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review.基于纳米材料的肺癌治疗新进展：综述。
Curr Med Chem. 2023;30(3):335-355. doi: 10.2174/0929867328666210810160901.
5
Lung Cancer (LC) in HIV Positive Patients: Pathogenic Features and Implications for Treatment.HIV 阳性患者的肺癌（LC）：发病特征及治疗意义。
Int J Mol Sci. 2020 Feb 26;21(5):1601. doi: 10.3390/ijms21051601.
6
Highlights from the 20th International Symposium on HIV and Emerging Infectious Diseases (ISHEID) 16-18 May 2018, Marseille, France: from HIV and comorbidities to global health.2018年5月16日至18日于法国马赛举行的第20届国际艾滋病毒与新发传染病研讨会（ISHEID）亮点：从艾滋病毒与合并症到全球健康。
J Virus Erad. 2018 Jul 1;4(3):196-207. doi: 10.1016/S2055-6640(20)30271-5.
健康老年人和肺癌患者的T细胞亚群：古巴研究的见解
Front Immunol. 2017 Feb 14;8:146. doi: 10.3389/fimmu.2017.00146. eCollection 2017.
4
HIV-Associated Lung Cancer.艾滋病相关肺癌。
Oncol Res Treat. 2017;40(3):88-92. doi: 10.1159/000458442. Epub 2017 Feb 20.
5
Immunodeficiency, AIDS-related pneumonia, and risk of lung cancer among HIV-infected individuals.HIV感染者中的免疫缺陷、艾滋病相关肺炎及肺癌风险
AIDS. 2017 Apr 24;31(7):989-993. doi: 10.1097/QAD.0000000000001434.
6
Non-infectious pulmonary disorders in HIV.HIV相关的非感染性肺部疾病
Expert Rev Respir Med. 2017 Mar;11(3):209-220. doi: 10.1080/17476348.2017.1288101. Epub 2017 Feb 3.
7
First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study.一线塞瑞替尼与铂类化疗用于晚期ALK 重排非小细胞肺癌（ASCEND-4）：一项随机、开放标签、III 期研究。
Lancet. 2017 Mar 4;389(10072):917-929. doi: 10.1016/S0140-6736(17)30123-X. Epub 2017 Jan 24.
8
Immunological and infectious risk factors for lung cancer in US veterans with HIV: a longitudinal cohort study.美国 HIV 感染者肺癌的免疫和感染危险因素：一项纵向队列研究。
Lancet HIV. 2017 Feb;4(2):e67-e73. doi: 10.1016/S2352-3018(16)30215-6. Epub 2016 Dec 2.
9
Risk of Cancer among Commercially Insured HIV-Infected Adults on Antiretroviral Therapy.接受抗逆转录病毒治疗的商业保险HIV感染成年患者的癌症风险。
J Cancer Epidemiol. 2016;2016:2138259. doi: 10.1155/2016/2138259. Epub 2016 Nov 2.
10
Swaziland HIV Incidence Measurement Survey (SHIMS): a prospective national cohort study.斯威士兰艾滋病毒发病率测量调查（SHIMS）：一项前瞻性全国队列研究。
Lancet HIV. 2017 Feb;4(2):e83-e92. doi: 10.1016/S2352-3018(16)30190-4. Epub 2016 Nov 16.