Dermatology Unit "Daniele Innocenzi," Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.
Dermatol Ther. 2018 Jul;31(4):e12599. doi: 10.1111/dth.12599. Epub 2018 Apr 11.
Hidradenitis suppurativa (HS) is a chronic disorder of terminal follicular epithelium in the apocrine gland-bearing areas. The long term therapy is based mainly on topical and/or systemic antibiotic use that could result in antibiotic resistance. The aim of our study was to present the real-life experience based on the efficacy and tolerability of a novel lotion containing triethyl-citrate, ethyl-linoleate, and g-peptide-10 in the treatment of mild to moderate HS that has already shown effectiveness in acne treatment. This was an open-label study on 30 patients of both sexes affected by HS. Patients were divided into two groups: 15 with Hurley I and 15 with Hurley II-III. The subjects were treated with the topical lotion, three-times-daily for eight weeks, with control at 4 (T ) and eight weeks (T ). Any other concomitant treatment (both topical and/or systemic) was avoided during study period. Improvement was observed in both Sartorius score grading system and inflammatory and noninflammatory lesion counts. The novel lotion has proved to be effective and well-tolerated topical agent alone or in association with other topical and/or systemic tratments in HS, without side effects.
化脓性汗腺炎（HS）是一种发生于顶泌汗腺分布区域的终末毛囊上皮慢性疾病。长期治疗主要基于局部和/或全身使用抗生素，但可能导致抗生素耐药。我们的研究旨在介绍一种新型洗剂的实际应用经验，该洗剂含有柠檬酸三乙酯、亚油酸乙酯和 g-肽-10，已显示出在痤疮治疗中的有效性，用于治疗轻至中度 HS 的疗效和耐受性。这是一项针对 30 名患有 HS 的男女患者的开放性研究。患者分为两组：15 名 Hurley I 期和 15 名 Hurley II-III 期。受试者每天接受三次局部洗剂治疗，持续 8 周，在第 4 周（T ）和第 8 周（T ）进行对照。研究期间避免使用任何其他伴随治疗（局部和/或全身）。Sartorius 评分分级系统以及炎症和非炎症病变计数均显示出改善。新型洗剂已被证明是一种有效的、单独使用或与其他局部和/或全身治疗联合使用的、耐受性良好的局部药物，没有副作用。
