Fouad Magdy, Fouad Yasser Mahrous, Mokareb Hamdy Ahmed, Mohamed Elham Ahmed, Abdel-Rehim Dalia Mohammed
Gastroenterology and Hepatology Unit, Tropical Medicine Department, Faculty of Medicine, El-Minia University, Minya, Egypt.
Internal Medicine Department, Faculty of Medicine, El-Minia University, Minya, Egypt.
Clin Endosc. 2018 Jul;51(4):357-361. doi: 10.5946/ce.2017.166. Epub 2018 Apr 11.
BACKGROUND/AIMS: Eosinophilic esophagitis (EoE) is gaining importance in the diagnosis of upper gastrointestinal (UGI) symptoms. Diagnosis is based on the clinical presentation of esophageal dysfunction and pathological findings in the absence of other causes of tissue eosinophilia. Our study was designed to evaluate EoE prevalence in patients with UGI symptoms in our locality (El-Minia, Egypt).
This single-center, cross-sectional study recruited all patients with UGI symptoms who agreed for endoscopic evaluation. Esophageal biopsy samples were obtained and histological evaluation for the presence of eosinophils was performed for every patient. EoE was defined when at least 15 eosinophils were present in a single high-power field, in the absence of other causes of esophageal eosinophilia.
Between 2013 and 2015, 218 of 476 adult patients with UGI symptoms underwent upper endoscopy after giving consent. Among the 218 patients, only 4 (1.87%) had the diagnosis of EoE based on the presence of eosinophils in esophageal biopsies and exclusion of other causes of esophageal eosinophilia. Three patients with EoE presented mainly with dysphagia (75%) and/or other UGI symptoms, such as heartburn.
We observed a low prevalence of EoE in our locality. The diagnosis of EoE should be considered in patients with dysphagia and/or heartburn.
背景/目的：嗜酸性粒细胞性食管炎（EoE）在诊断上消化道（UGI）症状方面日益受到重视。诊断基于食管功能障碍的临床表现以及在不存在其他导致组织嗜酸性粒细胞增多原因的情况下的病理发现。我们的研究旨在评估我们当地（埃及明亚）有UGI症状患者中EoE的患病率。
这项单中心横断面研究纳入了所有同意接受内镜评估的有UGI症状的患者。获取食管活检样本，并对每位患者进行嗜酸性粒细胞存在情况的组织学评估。当在单个高倍视野中至少有15个嗜酸性粒细胞存在且不存在其他食管嗜酸性粒细胞增多的原因时，定义为EoE。
在2013年至2015年期间，476名有UGI症状的成年患者中有218名在给予同意后接受了上消化道内镜检查。在这218名患者中，只有4名（1.87%）基于食管活检中嗜酸性粒细胞的存在以及排除其他食管嗜酸性粒细胞增多的原因而被诊断为EoE。3名EoE患者主要表现为吞咽困难（75%）和/或其他UGI症状，如烧心。
我们观察到我们当地EoE的患病率较低。对于有吞咽困难和/或烧心的患者应考虑EoE的诊断。
