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铂类化疗后肺腺癌患者外周表达HLA-DR的中间型和经典型单核细胞的恢复情况

Restoration of Peripheral Intermediate and Classical Monocytes Expressing HLA-DR in Patients With Lung Adenocarcinoma After Platinum-Based Chemotherapy.

作者信息

Rivas-Fuentes Selma, Iglesias Anjarath Higuera, Trejo Ana García, Castro Daniel Yair Chavarría, Figueroa Norma Inclán, Pérez Teresa Aguirre, Saldaña Renata Báez, Rosete Patricia Gorocica

机构信息

1 Department of Biochemistry Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas," Mexico City, Mexico.

2 Department of Clinical Epidemiology Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas," Mexico City, Mexico.

出版信息

Technol Cancer Res Treat. 2018 Jan 1;17:1533033818764720. doi: 10.1177/1533033818764720.

DOI:10.1177/1533033818764720
PMID:29642771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5900825/
Abstract

Lung adenocarcinoma represents one of the lung cancer subtypes with major prevalence. Accumulating evidence indicates that the immune system plays an important role in the evolution of the neoplastic process; additionally, several reports suggest that chemotherapy has an immunomodulatory effect. In order to identify the peripheral subpopulations of leukocytes that may change after chemotherapy, we evaluated several peripheral immune subpopulations of monocytes and lymphocytes by multicolor flow cytometry. In addition, we also measured cytokines and growth factors on plasma in order to evaluate the pro-inflammatory context in patients with lung adenocarcinoma after chemotherapy. We found that HLA-DR classical and intermediate monocytes were decreased in patients before chemotherapy, compared to controls. After chemotherapy, the relative percentage of those subpopulations was restored. In addition, interleukin 1β, interleukin 12, and interleukin 5 were increased after chemotherapy compared to prechemotherapy levels, while MIP-1β was decreased.

摘要

肺腺癌是肺癌的主要亚型之一。越来越多的证据表明，免疫系统在肿瘤发生发展过程中起重要作用；此外，一些报告表明化疗具有免疫调节作用。为了确定化疗后可能发生变化的外周血白细胞亚群，我们通过多色流式细胞术评估了单核细胞和淋巴细胞的多个外周免疫亚群。此外，我们还检测了血浆中的细胞因子和生长因子，以评估化疗后肺腺癌患者的促炎环境。我们发现，与对照组相比，化疗前患者的HLA-DR经典型和中间型单核细胞减少。化疗后，这些亚群的相对百分比恢复。此外，与化疗前水平相比，化疗后白细胞介素1β、白细胞介素12和白细胞介素5增加，而巨噬细胞炎性蛋白1β减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/3071879d9c85/10.1177_1533033818764720-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/bf08fdeea746/10.1177_1533033818764720-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/98617b2e22ca/10.1177_1533033818764720-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/21505b872916/10.1177_1533033818764720-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/5de2811e8557/10.1177_1533033818764720-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/3071879d9c85/10.1177_1533033818764720-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/bf08fdeea746/10.1177_1533033818764720-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/98617b2e22ca/10.1177_1533033818764720-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/21505b872916/10.1177_1533033818764720-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/5de2811e8557/10.1177_1533033818764720-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2389/5900825/3071879d9c85/10.1177_1533033818764720-fig5.jpg

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