Kang Jing-Wei, Yang Wei-Hsiang, Chi Jia-En, Chen Wei-Ta
School of Medicine, College of Medicine, Taipei Medical University.
Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University.
Acta Cardiol Sin. 2018 Mar;34(2):152-158. doi: 10.6515/ACS.201803_34(2).20171117A.
Ventricular premature complexes (VPCs) with a burden higher than 10% to 20% of total daily heart beats can cause VPC-induced cardiomyopathy. The systolic blood pressure response (SBPR) is the difference between the SBP during maximal exercise and rest. A low SBPR was recently identified to be a marker of cardiomyopathy. The aim of this manuscript was to clarify the association between VPC burden and SBPR.
From January to December 2015, all patients with a VPC burden larger than 240 beats/day on Holter recordings and treadmill exercise tests were enrolled. The patients with a heart rhythm other than sinus rhythm, coronary artery disease, and severe cardiomyopathy were excluded. The SBPR was measured during a treadmill test. The basic characteristics and echocardiographic findings were collected.
All patients were classified into three groups: Group 1; 240-1,000 VPCs/day (n = 78), Group 2; 1,000-10,000 VPCs/day (n = 54), and Group 3; > 10,000 VPCs/day (n = 21). Group 1 had a higher SBPR than the other groups. Multivariate analysis revealed that only VPC burden was associated with SBPR. Receiver operating characteristic curve analysis showed that a VPC burden > 1,055 beats/day predicted a SBPR < 40 mmHg. The results were consistent in all subgroups. There were no significant differences in echocardiographic findings among the groups.
AVPC burden higher than 1,055 beats/day was associated with a reduced SBPR.
室性早搏（VPCs）负荷超过每日总心跳数的10%至20%可导致VPCs诱发的心肌病。收缩压反应（SBPR）是最大运动时与静息时收缩压（SBP）的差值。最近发现低SBPR是心肌病的一个标志物。本研究的目的是阐明VPCs负荷与SBPR之间的关联。
纳入2015年1月至12月期间动态心电图记录和跑步机运动试验中VPCs负荷大于240次/天的所有患者。排除心律不是窦性心律、患有冠状动脉疾病和严重心肌病的患者。在跑步机试验期间测量SBPR。收集基本特征和超声心动图检查结果。
所有患者分为三组：第1组，240 - 1000次/天VPCs（n = 78）；第2组，1000 - 10000次/天VPCs（n = 54）；第3组，>10000次/天VPCs（n = 21）。第1组的SBPR高于其他组。多因素分析显示，仅VPCs负荷与SBPR相关。受试者工作特征曲线分析表明，VPCs负荷>1055次/天预测SBPR<40 mmHg。所有亚组的结果均一致。各组间超声心动图检查结果无显著差异。
VPCs负荷高于1055次/天与SBPR降低相关。
