与去氨加压素鼻喷雾剂相关的中心性浆液性脉络膜视网膜病变：因果关系还是不幸的关联？
Central Serous Chorioretinopathy Associated with Desmopressin Nasal Spray: Causality or Unfortunate Association.
作者信息
Kisma Nacima, Loukianou Eleni, Pal Bishwanath
机构信息
Moorfields Eye Hospital NHS, London, United Kingdom.
出版信息
Case Rep Ophthalmol. 2018 Feb 6;9(1):120-125. doi: 10.1159/000485912. eCollection 2018 Jan-Apr.
PURPOSE
To describe the possible association between central serous chorioretinopathy (CSCR) and desmopressin use.
METHODS
The case histories of 2 middle-aged men with CSCR using desmopressin nasal spray were studied.
RESULTS
The diagnosis of CSCR was made on the basis of clinical features and ancillary testing (fluorescein angiography and optical coherence tomography). Both patients were using desmopressin nasal spray for polyuria when they developed the first ocular symptoms. Both of them also had an independent risk factor for developing CSCR.
CONCLUSION
We suggest that desmopressin-induced hypercortisolism might implicate the development of CSCR in some patients. A larger study on patients using desmopressin nasal spray would be beneficial to confirm the possible association between this form of therapy and the development of CSCR.
目的
描述中心性浆液性脉络膜视网膜病变（CSCR）与去氨加压素使用之间可能存在的关联。
方法
研究了2例使用去氨加压素鼻喷雾剂的中年CSCR男性患者的病史。
结果
CSCR的诊断基于临床特征及辅助检查（荧光素血管造影和光学相干断层扫描）。两名患者在出现首批眼部症状时均因多尿而使用去氨加压素鼻喷雾剂。他们两人也都有发生CSCR的独立危险因素。
结论
我们认为，去氨加压素诱发的高皮质醇血症可能在某些患者中与CSCR的发生有关。对使用去氨加压素鼻喷雾剂的患者进行更大规模的研究，将有助于证实这种治疗方式与CSCR发生之间可能存在的关联。
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