Spoerri Andreas, Koletsi Despina, Eliades Theodore
Clinic of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.
Front Physiol. 2018 Mar 28;9:303. doi: 10.3389/fphys.2018.00303. eCollection 2018.
External root resorption constitutes an adverse effect of orthodontic treatment. The aim of the present meta-analysis was to identify the effect of induced intrinsic/ hormone-like molecules such as prostaglandins, interleukins and others on external root resorption after orthodontic tooth movement in experimental animals An electronic database search of the literature was performed (Medline via PubMed, EMBASE, LILACS, and Open Gray). Search terms included root resorption, tooth movement and animal type. Risk of bias assessment was made using the SYRCLE guidelines for animal studies and reporting quality was assessed through ARRIVE. Random effects meta-analysis was performed for the outcome root resorption after orthodontic tooth movement. Of the 124 articles initially retrieved, 13 were eligible for inclusion in the systematic review, while only 2 were included in the quantitative synthesis. Five studies investigated the effect of Prostaglandin E2, four studies the effect of Thyroxine, two the effect of Calcium ions (Ca++), while the rest investigated Misoprostol, Interleukin-12 and Interleukin-4. Risk of Bias in all studies was judged to be high overall, while reporting quality was suboptimal. According to the quantitative synthesis, there was no difference in root resorption after orthodontic tooth movement when Prostaglandin E2 coupled with Ca++ was administered in comparison to no substance administration (SMD: 0.48 mm; 95% CI: -0.22, 1.19; = 0.18). Overall, there was no evidence to suggest a variation in root resorption when Prostaglandin E2 and Ca++ were administered, while there is an overriding need for further high quality experimental studies to inform available evidence on the effect of intrinsic substances on external root resorption.
牙根外吸收是正畸治疗的一种不良反应。本荟萃分析的目的是确定前列腺素、白细胞介素等内源性/激素样分子对实验动物正畸牙齿移动后牙根外吸收的影响。通过电子数据库检索文献（通过PubMed检索Medline、EMBASE、LILACS和Open Gray）。检索词包括牙根吸收、牙齿移动和动物类型。使用SYRCLE动物研究指南进行偏倚风险评估，并通过ARRIVE评估报告质量。对正畸牙齿移动后牙根吸收的结果进行随机效应荟萃分析。在最初检索的124篇文章中，13篇符合纳入系统评价的标准，而只有2篇纳入定量综合分析。五项研究调查了前列腺素E2的影响，四项研究调查了甲状腺素的影响，两项研究调查了钙离子（Ca++）的影响，其余研究调查了米索前列醇、白细胞介素-12和白细胞介素-4的影响。所有研究的偏倚风险总体判断为高，而报告质量欠佳。根据定量综合分析，与未给药相比，给予前列腺素E2联合Ca++后正畸牙齿移动后的牙根吸收没有差异（标准化均数差：0.48mm；95%可信区间：-0.22，1.19；P=0.18）。总体而言，没有证据表明给予前列腺素E2和Ca++时牙根吸收有变化，而迫切需要进一步的高质量实验研究来为内源性物质对牙根外吸收影响的现有证据提供信息。
