光生物调节对人类正畸牙齿移动过程中外源性牙根吸收的影响——一项系统评价与Meta分析

Impact of photobiomodulation on external root resorption during orthodontic tooth movement in humans - A systematic review and meta-analysis.

作者信息

Nayyer Nida, Tripathi Tulika, Ganesh Gayatri, Rai Priyank

机构信息

Department of Orthodontics & Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, MAMC Complex, Bahadur Shah Zafar Marg, New Delhi, 110002, India.

出版信息

J Oral Biol Craniofac Res. 2022 Jul-Aug;12(4):469-480. doi: 10.1016/j.jobcr.2022.05.014. Epub 2022 May 31.

DOI:10.1016/j.jobcr.2022.05.014

PMID:35692967

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9178480/

Abstract

BACKGROUND

Photobiomodulation has been gaining traction as a plausible therapy to control orthodontically induced root resorption.

AIM

The aim of the present review was to systematically appraise randomized controlled trials conducted to study the influence of photobiomodulation on external root resorption during orthodontic movement in humans.

METHOD

ology - A systematic search was carried out employing keywords in various electronic databases namely MEDLINE (Pubmed), Cochrane Library, Google Scholar, Semantic Scholar, ScienceDirect and Opengrey.eu for studies up to March 2020. Pre-defined inclusion and exclusion criteria were used to select the studies. Data extraction was carried out and the risk of bias was assessed using Cochrane Risk of Bias tool. Meta-analysis was conducted using random effects model for selected studies. Subgroup analysis was conducted for resorption on each axial surface of the tooth root viz. mesial, buccal, distal and palatal as well as for vertical thirds viz. cervical, middle and apical third. Summary of Findings was formulated according to GRADE Profile.

RESULTS

The search retrieved 1509 results out of which six studies were included for the systematic review. Two studies showed low overall risk of bias and the remaining four showed unclear risk of bias. The meta-analysis was conducted for three studies with an overall sample size of 120 teeth which showed a pooled mean difference of 0.08 (95% CI 0.15 - (-0.02) to 1.96, p=<0.0001) in favour of photobiomodulation group with respect to mean total resorption per tooth. I index revealed 88% heterogeneity.

CONCLUSION

It is concluded that there is moderate grade of evidence to suggest beneficial effect of photobiomodulation on root resorption. Further high-quality randomized controlled trials with standardized intervention parameters are recommended.

REGISTRATION

PROSPERO registration number - CRD42020167291.

摘要

背景

光生物调节作为一种控制正畸诱导牙根吸收的可行疗法，正逐渐受到关注。

目的

本综述的目的是系统评价为研究光生物调节对人类正畸移动过程中外侧牙根吸收的影响而进行的随机对照试验。

方法

采用关键词在多个电子数据库（即MEDLINE（PubMed）、Cochrane图书馆、谷歌学术、语义学者、ScienceDirect和Opengrey.eu）中进行系统检索，以查找截至2020年3月的研究。使用预先定义的纳入和排除标准选择研究。进行数据提取，并使用Cochrane偏倚风险工具评估偏倚风险。对选定的研究使用随机效应模型进行荟萃分析。对牙根每个轴面（即近中、颊侧、远中及腭侧）以及垂直三分法（即颈部、中部和根尖三分之一）的吸收情况进行亚组分析。根据GRADE概况制定结果总结。

结果

检索共获得1509条结果，其中六项研究被纳入系统评价。两项研究显示总体偏倚风险较低，其余四项研究显示偏倚风险不明确。对三项研究进行了荟萃分析，总体样本量为120颗牙齿，结果显示光生物调节组每颗牙齿的平均总吸收量的合并平均差为0.08（95%CI 0.15 - (-0.02)至1.96，p =<0.0001）。I指数显示异质性为88%。