Itoh H, Nakao K, Yamada T, Morii N, Shiono S, Sugawara A, Saito Y, Mukoyama M, Arai H, Imura H
Department of Medicine, Kyoto University School of Medicine, Japan.
Hypertension. 1988 Feb;11(2 Pt 2):I57-61. doi: 10.1161/01.hyp.11.2_pt_2.i57.
To elucidate the modulatory role of the brain renin-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 microgram significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 +/- 57 pg/ml; angiotensin II 100 ng, 1110 +/- 320 pg/ml, p less than 0.01; angiotensin II 1 microgram, 1055 +/- 60 pg/ml, p less than 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin II-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V1-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renin-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central alpha-adrenergic neural pathway.
为阐明脑肾素-血管紧张素系统在调节心脏心房钠尿肽（ANF）分泌中的调节作用，在清醒无拘束大鼠中检测了脑室内给予血管紧张素II对血浆ANF水平的影响。给予100 ng和1 μg剂量的血管紧张素II显著增强了通过输注3 ml生理盐水进行容量负荷诱导的ANF分泌（血浆ANF水平峰值：对照组，220±57 pg/ml；血管紧张素II 100 ng，1110±320 pg/ml，p<0.01；血管紧张素II 1 μg，1055±60 pg/ml，p<0.01）。单独注射血管紧张素II对基础血浆ANF水平无显著影响。预先静脉注射血管升压素的V1受体拮抗剂或脑室内注射酚妥拉明可显著减弱中枢血管紧张素II诱导的ANF分泌。这些结果表明，脑肾素-血管紧张素系统通过刺激血管升压素分泌或激活中枢α-肾上腺素能神经通路来调节容量负荷反应中的ANF分泌。
