Penson Richard T, Wenzel Lari B, Vergote Ignace, Cella David
Harvard Medical School, Boston, MA, USA.
College of Medicine University of California, Irvine, CA, USA.
Int J Gynaecol Obstet. 2006 Nov;95 Suppl 1:S247-S257. doi: 10.1016/S0020-7292(06)60040-4.
Quality of life (QOL) is a fundamental consideration for patients with life threatening diseases. Major evolving paradigms are discussed: improved QOL with laparoscopic surgery, the impact on QOL of intraperitoneal chemotherapy for optimally cytoreduced ovarian cancer, combination therapy, sexuality, and survivorship. The goals of treatment for many patients with gynecologic tumors remain largely palliative, and patient reported QOL is the primary outcome determining the utility of treatment. Particularly in this area, QOL endpoints are increasingly important in clinical trials. The QOL issues facing gynecologic cancer patients, the use of validated QOL instruments, recent advances in the evaluation of interventions, and changes in concepts related to QOL are reviewed.
生活质量（QOL）是威胁生命疾病患者的一项基本考量因素。文中讨论了主要的发展范式：腹腔镜手术改善生活质量、腹腔内化疗对最佳细胞减灭的卵巢癌患者生活质量的影响、联合治疗、性功能及生存。许多妇科肿瘤患者的治疗目标很大程度上仍是姑息性的，患者报告的生活质量是决定治疗效用的主要结果。特别是在这一领域，生活质量终点在临床试验中日益重要。本文综述了妇科癌症患者面临的生活质量问题、经过验证的生活质量评估工具的使用、干预评估的最新进展以及与生活质量相关概念的变化。
