Zhang Qiang, Chen Xinguang, Chen Shunan, Ye Yinlong, Luo Jiancheng, Li Juanjuan, Yu Siyang, Liu Hui, Liu Zhitao
Southeast Asian J Trop Med Public Health. 2017 Jan;48(1):189-96.
Honey poisoning cases occur in southwestern China. In this case series, we attempted to determine the symptoms and causes of honey poisoning from 2007 to 2012 in southwestern China. We also conducted a quantitative melissopalynological analysis of honey samples. During the study period, 31 honey poisoning cases occurred in the study location, all during July to August. All the cases occurred after consuming at least 100 grams of honey. The most frequent symptoms were nausea and vomiting (100%), abdominal pain (90.3%), diarrhea (74.2%), palpitations (61.3%), dizziness (54.8%), chest congestion (48.4%) and dyspnea (48.4%). Severe cases developed oliguria/anuria, twitch, hematuria, ecchymosis or hematochezia. The median time from ingestion to onset of symptoms was 29 hours. Eight patients died (mortality rate: 25.8%). The pollen of Tripterygium hypoglaucum (a plant with poisonous nectar and pollen) was detected in 22 of 29 honey samples examined (75.9%). The results of pollen analysis were consistent with the clinical findings of previous cases. T. hypoglaucum appears to be the cause of honey poisoning in southwestern China. Honey poisoning should be included in the differential diagnosis of patients who consume honey in this region and develop symptoms of food poisoning.
蜂蜜中毒病例在中国西南部时有发生。在这个病例系列中，我们试图确定2007年至2012年中国西南部蜂蜜中毒的症状和原因。我们还对蜂蜜样本进行了定量蜂蜜花粉分析。在研究期间，研究地点共发生31例蜂蜜中毒病例，均发生在7月至8月。所有病例均在食用至少100克蜂蜜后发病。最常见的症状是恶心和呕吐（100%）、腹痛（90.3%）、腹泻（74.2%）、心悸（61.3%）、头晕（54.8%）、胸部闷塞（48.4%）和呼吸困难（48.4%）。严重病例出现少尿/无尿、抽搐、血尿、瘀斑或便血。从摄入蜂蜜到出现症状的中位时间为29小时。8名患者死亡（死亡率：25.8%）。在29份检测的蜂蜜样本中，有22份（75.9%）检测到了昆明山海棠（一种花蜜和花粉有毒的植物）的花粉。花粉分析结果与先前病例的临床发现一致。昆明山海棠似乎是中国西南部蜂蜜中毒的原因。对于该地区食用蜂蜜后出现食物中毒症状的患者，应将蜂蜜中毒纳入鉴别诊断。
