a Faculty of Chemical Engineering , Section of Chemistry, Aristotle University of Thessaloniki , Thessaloniki , Greece.
J Microencapsul. 2018 May;35(3):229-240. doi: 10.1080/02652048.2018.1462415. Epub 2018 Apr 23.
Grapes (Vitis vinifera) are produced in large amounts worldwide and mostly are used for winemaking. Their untreated wastes are rich in valuable secondary metabolites, such as phenolics. Thus, in this study, white and red wine wastes (Malagouzia and Syrah variety) were investigated for their added value phenolics, which were analysed by high performance liquid chromatography (HPLC) and electrospray ionisation-mass spectrometry (ESI/MS) and subsequently encapsulated in several polymers. Extracts from all wastes gave high amounts of total phenolics (13 ± 2.72-22 ± 2.69 mg g) and possessed high antioxidant activity (67-97%). In addition to their significant antibacterial activity against gram-negative and gram-positive bacteria, interesting results were also obtained from their anti-inflammatory and antiplatelet activity, in vitro. Encapsulation of the extracts was selective, leaving out most of sugars and other organic compounds when alginate-chitosan was used. Encapsulation efficiency recorded for all extracts ranged from 55% to 79%. Release studies were also performed in several solutions aiming in their commercial use in food and pharmaceutical industries.
葡萄（Vitis vinifera）在全球范围内大量生产，主要用于酿酒。其未经处理的废料富含有价值的次生代谢产物，如酚类物质。因此，在这项研究中，我们研究了白葡萄酒和红葡萄酒废料（Malagouzia 和 Syrah 品种）的附加值酚类物质，并用高效液相色谱（HPLC）和电喷雾电离-质谱（ESI/MS）进行了分析，并随后将其封装在几种聚合物中。所有废料提取物均含有大量总酚类物质（13±2.72-22±2.69mg/g），具有很高的抗氧化活性（67-97%）。除了对革兰氏阴性和革兰氏阳性菌具有显著的抗菌活性外，它们在体外还具有抗炎和抗血小板活性的有趣结果。当使用藻酸盐-壳聚糖时，提取物的封装具有选择性，除去了大部分糖和其他有机化合物。所有提取物的封装效率范围为 55%至 79%。还在几种溶液中进行了释放研究，旨在将其用于食品和制药行业的商业用途。
