CD16。培养的人单核细胞上受发育调控的IgG Fc受体。
CD16. Developmentally regulated IgG Fc receptors on cultured human monocytes.
作者信息
Clarkson S B, Ory P A
机构信息
Rosalind Russell Arthritis Research Laboratory, University of California, San Francisco 94102.
出版信息
J Exp Med. 1988 Feb 1;167(2):408-20. doi: 10.1084/jem.167.2.408.
We have demonstrated that one Fc receptor for IgG (FcR) (CD16) on cultured human monocytes appears to be a developmentally regulated membrane protein. This receptor appears to contain less carbohydrate (if any) than does its counterpart on human neutrophils. Expression of CD16 on cultured monocytes increases with respect to both percentage of positive cells and numbers of sites per cell with length of time in culture. This was in contrast to expression of other types of FcRs that either decreased (CDw32) or did not change (FcRp72). Unlike an FcR that binds monomeric IgG (FcRp72), expression of CD16 on monocytes from most normal individuals was not influenced by IFN-gamma. After 14 d in culture, CD16 appeared to be the predominant FcR on cultured monocytes, and was capable of mediating both ligand attachment and phagocytosis. These findings support the hypothesis that CD16 plays an important role in mediating immunophagocytosis.
我们已经证明，培养的人单核细胞上的一种IgG Fc受体（FcR）（CD16）似乎是一种受发育调控的膜蛋白。该受体所含碳水化合物（如果有的话）似乎比人中性粒细胞上的对应物少。培养的单核细胞上CD16的表达随着培养时间的延长，在阳性细胞百分比和每个细胞的位点数量方面均增加。这与其他类型FcR的表达情况形成对比，其他类型的FcR要么减少（CDw32），要么不变（FcRp72）。与结合单体IgG的FcR（FcRp72）不同，大多数正常个体单核细胞上CD16的表达不受干扰素-γ的影响。培养14天后，CD16似乎是培养的单核细胞上的主要FcR，并且能够介导配体附着和吞噬作用。这些发现支持了CD16在介导免疫吞噬作用中起重要作用的假说。
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