1Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-sen University,Guangzhou 510080,People's Republic of China.
3Division of Epidemiology,The Jockey Club School of Public Health and Primary Care,The Chinese University of Hong Kong,Hong Kong SAR,People's Republic of China.
Br J Nutr. 2018 Apr;119(8):957-964. doi: 10.1017/S0007114518000600.
Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017. Consumption of cruciferous vegetables was assessed using a validated FFQ. Dietary GSL and ITC were computed by using two food composition databases linking GSL and ITC contents in cruciferous vegetables with responses to the FFQ. The OR and 95 % CI were assessed by unconditional logistic regression after adjusting for the potential confounders. Significant inverse associations were found between consumption of cruciferous vegetables, GSL and ITC and breast cancer risk. The adjusted OR comparing the highest with the lowest quartile were 0·51 (95 % CI 0·41, 0·63) for cruciferous vegetables, 0·54 (95 % CI 0·44, 0·67) for GSL and 0·62 (95 % CI 0·50, 0·76) for ITC, respectively. These inverse associations were also observed in both premenopausal and postmenopausal women. Subgroup analysis by hormone receptor status found inverse associations between cruciferous vegetables, GSL and ITC and both hormone-receptor-positive or hormone-receptor-negative breast cancer. This study indicated that consumption of cruciferous vegetables, GSL and ITC was inversely associated with breast cancer risk among Chinese women.
尽管之前的研究已经调查了十字花科蔬菜的消费与乳腺癌风险之间的关联，但很少有研究关注十字花科蔬菜中的生物活性成分——硫代葡萄糖苷（GSL）和异硫氰酸酯（ITC）与乳腺癌风险之间的关联。本研究旨在检验中国人群中十字花科蔬菜消费与 GSL 和 ITC 含量与乳腺癌风险之间的关联。这项病例对照研究于 2007 年 6 月至 2017 年 3 月期间招募了 1485 名病例和 1506 名对照。通过验证过的 FFQ 评估十字花科蔬菜的消费情况。通过两个食物成分数据库计算饮食中的 GSL 和 ITC，该数据库将 GSL 和 ITC 含量与对 FFQ 的响应联系起来。调整潜在混杂因素后，采用非条件逻辑回归评估 OR 和 95%CI。研究发现，十字花科蔬菜、GSL 和 ITC 的消费与乳腺癌风险呈显著负相关。最高四分位与最低四分位相比，十字花科蔬菜、GSL 和 ITC 的调整 OR 分别为 0.51（95%CI 0.41，0.63）、0.54（95%CI 0.44，0.67）和 0.62（95%CI 0.50，0.76）。这些负相关在绝经前和绝经后妇女中均有观察到。按激素受体状态进行的亚组分析发现，十字花科蔬菜、GSL 和 ITC 与激素受体阳性或激素受体阴性乳腺癌均呈负相关。本研究表明，在中国女性中，十字花科蔬菜、GSL 和 ITC 的消费与乳腺癌风险呈负相关。
