Xu Lei, Zhang Qi, Xie Qiang, Huang Bei, Dai Jian-Jun, Xu Jun, Xu Hua-Jian
School of Biology and Medical Engineering, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei University of Technology Hefei, 230009, P. R. China.
Chem Commun (Camb). 2018 Apr 26;54(35):4406-4409. doi: 10.1039/c8cc01568f.
An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C-F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C-F bond activation.
本文报道了一种前所未有的钯催化的三氟甲基活化反应。该反应成功的关键在于连续的β-F消除和三氟甲基的C-F键氧化加成的结合。它还代表了通过C-F键活化将α-三氟甲基酮作为结构单元的首次广泛应用。
