Anand Devireddy, Sun Zhengchang, Zhou Lei
School of Chemistry, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.
Org Lett. 2020 Mar 20;22(6):2371-2375. doi: 10.1021/acs.orglett.0c00568. Epub 2020 Mar 5.
-Difluoroalkene bearing a carbonyl group is a challenging target to synthesize by conventional methods. Herein we report a mild and concise route to access the target compounds through the visible-light-mediated direct β-C-H -difluoroallylation of aliphatic aldehydes and cyclic ketones. Upon a synergistic combination of photoredox catalysis and organocatalysis, various α-CF alkenes were employed as the -difluoroallylation reagents via the C-F bond cleavage.
含有羰基的二氟烯烃是通过传统方法合成具有挑战性的目标化合物。在此，我们报道了一种温和且简洁的路线，通过可见光介导的脂肪醛和环酮的直接β-C-H-二氟烯丙基化反应来获得目标化合物。在光氧化还原催化和有机催化的协同作用下，各种α-CF烯烃通过C-F键断裂用作二氟烯丙基化试剂。
