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新生儿破伤风:进展回顾

Neonatal tetanus: review of progress.

作者信息

Gasse F

机构信息

Expanded Programme on Immunization, World Health Organization, 1211 Geneva 27, Switzerland.

出版信息

Int J Gynaecol Obstet. 1995 Oct;50 Suppl 2:S67-S72. doi: 10.1016/0020-7292(95)02490-4.

DOI:10.1016/0020-7292(95)02490-4
PMID:29645166
Abstract

The target set for elimination of neonatal tetanus (NT) is less than one case par 1000 live births in every district of the world. NT will then be considered to have been removed as a major public health problem and fewer than 150 000 cases are expected to occur annually worldwide if the achievements are maintained. It is estimated for 1993 that over 700 000 neonatal deaths due to tetanus were in fact prevented by maternal immunization and clean delivery practices. About 480 000 (70%) of them were averted in only three countries: India, Bangladesh and Indonesia. Meanwhile, 91 others already have an estimated NT rate below 1 per 1000 live births nationwide. Of these, 50 countries may already have achieved the target in each of their districts. According to 1993 estimates half a million newborn deaths due to tetanus are still occurring worldwide, 80% of them in 12 countries. Out of 14 others where NT remains a major public health problem, 12 are in the African Region. Together, these 26 countries contribute 90% of the global incidence of NT. By 1995, major strides towards the elimination of NT can be made by using the high risk approach and immunization, including organizing Days of Tranquility where necessary. But for this to be accomplished, there must be sufficient political commitment and financial support of some US$ 30 million to carry out the program in the 26 priority countries.

摘要

消除新生儿破伤风(NT)的目标是全球每个地区每1000例活产中病例数少于1例。届时,NT将被视为已不再是一个主要的公共卫生问题,如果保持现有成果,预计全球每年发生的病例数将少于15万例。据估计,1993年通过孕产妇免疫和清洁接生做法,实际上预防了超过70万例因破伤风导致的新生儿死亡。其中约48万例(70%)仅在三个国家得以避免:印度、孟加拉国和印度尼西亚。与此同时,另有91个国家全国估计的NT发病率已低于每1000例活产1例。其中,50个国家可能其每个地区都已实现目标。根据1993年的估计,全球仍有50万例新生儿死于破伤风,其中80%发生在12个国家。在NT仍然是主要公共卫生问题的另外14个国家中,有12个在非洲区域。这26个国家合计占全球NT发病率的90%。到1995年,通过采用高风险方法和免疫措施,包括在必要时组织“平静日”活动,可以在消除NT方面取得重大进展。但要实现这一目标,必须有足够的政治承诺和3000万美元左右的财政支持,以便在26个优先国家开展该计划。

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