倾斜涡旋流介导的多组分光催化和过渡金属催化反应。
Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions.
机构信息
School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Centre for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia.
出版信息
Chemistry. 2018 Jun 21;24(35):8869-8874. doi: 10.1002/chem.201801109. Epub 2018 Jun 1.
The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A -coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A -coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.
在涡旋流控装置（VFD）中，倾斜快速旋转管内形成的动态薄膜在促进多组分反应（MCR）方面非常有效，这些反应可以是光催化或金属介导的过程。在这里，我们通过使用两种已知的 MCR（Ugi 型三组分反应和 A 偶联反应）展示了 VFD 的实用性。Ugi 型反应可以在微流控平台的受限或连续流动操作模式下进行，而 A 偶联反应则针对受限操作模式进行了优化。测试的示例反应时间短，产率很高。
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