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神经内分泌调节的神经肽和甾体激素介质。

Neuropeptide and steroid hormone mediators of neuroendocrine regulation.

机构信息

Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Laboratory of Pharmacology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil.

出版信息

J Neuroendocrinol. 2018 Oct;30(10):e12599. doi: 10.1111/jne.12599. Epub 2018 Aug 7.

DOI:10.1111/jne.12599
PMID:29645316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6181757/
Abstract

To maintain the health and well-being of all mammals, numerous aspects of physiology are controlled by neuroendocrine mechanisms. These mechanisms ultimately enable communication between neurones and glands throughout the body and are centrally mediated by neuropeptides and/or steroid hormones. A recent session at the International Workshop in Neuroendocrinology highlighted the essential roles of some of these neuropeptide and steroid hormone mediators in the neuroendocrine regulation of stress-, reproduction- and behaviour-related processes. Accordingly, the present review highlights topics presented in this session, including the role of the neuropeptides corticotrophin-releasing factor and gonadotrophin-releasing hormone in stress and reproductive physiology, respectively. Additionally, it details an important role for gonadal sex steroids in the development of behavioural sex preference.

摘要

为了维持所有哺乳动物的健康和福祉,许多生理学方面都受到神经内分泌机制的控制。这些机制最终使身体各处的神经元和腺体之间能够进行通讯,并由神经肽和/或类固醇激素在中枢介导。最近一次神经内分泌学国际研讨会的一个分会强调了其中一些神经肽和类固醇激素介质在应激、生殖和行为相关过程的神经内分泌调节中的重要作用。因此,本综述重点介绍了该分会提出的主题,包括促肾上腺皮质激素释放因子和促性腺激素释放激素分别在应激和生殖生理学中的作用。此外,它详细介绍了性腺性激素在性行为偏好发展中的重要作用。

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GnRH-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion.促性腺激素释放激素(1-5)激活基质金属蛋白酶-9以释放表皮生长因子并促进细胞侵袭。
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Male rats with same sex preference show high experimental anxiety and lack of anxiogenic-like effect of fluoxetine in the plus maze test.具有同性偏好的雄性大鼠在高架十字迷宫试验中表现出高度的实验性焦虑,且氟西汀无致焦虑样效应。
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