心房利钠肽对体外培养的大鼠下丘脑乙酰胆碱诱导促肾上腺皮质激素释放因子释放的影响。
Effect of atrial natriuretic peptide on acetylcholine-induced release of corticotropin-releasing factor from rat hypothalamus in vitro.
作者信息
Takao T, Hashimoto K, Ota Z
机构信息
Third Department of Internal Medicine, Okayama University Medical School, Japan.
出版信息
Life Sci. 1988;42(12):1199-203. doi: 10.1016/0024-3205(88)90550-4.
Effect of rat atrial natriuretic peptide (rANP) on acetylcholine-induced release of corticotropin-releasing factor (CRF) from the rat hypothalamus was studied in vitro using perifusion method. Perifused acetylcholine at 100 and 1000 ng/ml evoked significant CRF release, whereas norepinephrine at 10, 100 and 1000 ng/ml did not show a definite effect on CRF release. Continuous administration of alpha-rANP(1-28) (20ng/ml) inhibited the acetylcholine (100ng/ml)-induced CRF release. It is likely that ANP is involved in the regulation of CRF release.
采用体外灌流法研究了大鼠心房利钠肽（rANP）对乙酰胆碱诱导的大鼠下丘脑促肾上腺皮质激素释放因子（CRF）释放的影响。100和1000 ng/ml的灌流乙酰胆碱可引起显著的CRF释放，而10、100和1000 ng/ml的去甲肾上腺素对CRF释放未显示出明确影响。持续给予α-rANP(1-28)（20 ng/ml）可抑制乙酰胆碱（100 ng/ml）诱导的CRF释放。心房利钠肽可能参与了促肾上腺皮质激素释放因子释放的调节。
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