Takao T, Hashimoto K, Ota Z
Third Department of Internal Medicine, Okayama University Medical School, Japan.
Life Sci. 1988;42(12):1199-203. doi: 10.1016/0024-3205(88)90550-4.
Effect of rat atrial natriuretic peptide (rANP) on acetylcholine-induced release of corticotropin-releasing factor (CRF) from the rat hypothalamus was studied in vitro using perifusion method. Perifused acetylcholine at 100 and 1000 ng/ml evoked significant CRF release, whereas norepinephrine at 10, 100 and 1000 ng/ml did not show a definite effect on CRF release. Continuous administration of alpha-rANP(1-28) (20ng/ml) inhibited the acetylcholine (100ng/ml)-induced CRF release. It is likely that ANP is involved in the regulation of CRF release.
采用体外灌流法研究了大鼠心房利钠肽（rANP）对乙酰胆碱诱导的大鼠下丘脑促肾上腺皮质激素释放因子（CRF）释放的影响。100和1000 ng/ml的灌流乙酰胆碱可引起显著的CRF释放，而10、100和1000 ng/ml的去甲肾上腺素对CRF释放未显示出明确影响。持续给予α-rANP(1-28)（20 ng/ml）可抑制乙酰胆碱（100 ng/ml）诱导的CRF释放。心房利钠肽可能参与了促肾上腺皮质激素释放因子释放的调节。
