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In vitro study of immunoreactive corticotropin-releasing factor release from the rat hypothalamus.

作者信息

Suda T, Yajima F, Tomori N, Demura H, Shizume K

出版信息

Life Sci. 1985 Oct 21;37(16):1499-505. doi: 10.1016/0024-3205(85)90181-x.

DOI:10.1016/0024-3205(85)90181-x
PMID:2995748
Abstract

Immunoreactive corticotropin-releasing factor (I-CRF) release from rat hypothalami was studied in vitro utilizing a perifusion of rat hypothalami and a rat CRF RIA. Basal release of I-CRF from the hypothalamus of adrenalectomized or hypophysectomized rats was higher than in that of normal rats. K+-induced I-CRF release was completely suppressed by omission of Ca++ from the medium. Dexamethasone suppressed I-CRF release from hypothalami, but not from median eminence (ME). C-AMP and angiotensin II had mild stimulatory effects on I-CRF release. These results suggest that 1) the feedback mechanism acts mainly on a higher level than ME, and 2) c-AMP and angiotensin II may be involved in CRF-releasing mechanism(s).

摘要

相似文献

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