Schuller E
Laboratoire de Neuro-Immunologie, Hôpital de la Salpêtrière, Paris.
Presse Med. 1988 Feb 6;17(4):155-60.
The occurrence of an intrathecal immune reaction, specific to the central nervous system, may reflect either a contemporary systemic immune reaction or a local process directly related to the disease observed. Analysis of this reaction proceeds in 3 stages: the intrathecal production of immunoglobulins is assessed; the specific antibody activity of the intrathecal immunoglobulins is compared with that observed in serum; possible variations in components of complement are investigated. These different data are derived from the examination of serum and cerebrospinal fluid samples obtained simultaneously. The results of the analysis help in determining the cause of the disease, enable the severity and potential prognostic value of the immune reaction to be assessed and provide precise information on the influence of treatment on the course of the reaction. Several examples (syphilis, AIDS, measles panencephalitis, multiple sclerosis) illustrate these results.
鞘内免疫反应（一种特定于中枢神经系统的反应）的发生，可能反映了当代的全身免疫反应，或者是与所观察到的疾病直接相关的局部过程。对这种反应的分析分三个阶段进行：评估鞘内免疫球蛋白的产生；将鞘内免疫球蛋白的特异性抗体活性与血清中的进行比较；研究补体成分可能的变化。这些不同的数据来自于同时采集的血清和脑脊液样本的检测。分析结果有助于确定疾病的病因，评估免疫反应的严重程度和潜在的预后价值，并提供有关治疗对反应进程影响的精确信息。几个例子（梅毒、艾滋病、麻疹全脑炎、多发性硬化症）说明了这些结果。
