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亚急性硬化性全脑炎患者脑脊液免疫球蛋白的免疫化学方面

Immunochemical aspects of cerebrospinal fluid immunoglobulins in patients with subacute sclerosing panencephalitis.

作者信息

Cernescu C, Strati I, Popescu L, Petrescu V

出版信息

Virologie. 1986 Apr-Jun;37(2):89-93.

PMID:3727399
Abstract

Unconcentrated cerebrospinal fluid (CSF) samples from 50 patients with subacute sclerosing panencephalitis (SSPE) were investigated by rocket immunoelectrophoresis (RIE) against anti-human IgG sera. Two patterns of immune precipitates were observed: precipitates with exclusively cathodal and precipitates with bipolar extension. Hemagglutination-inhibition tests against measles virus antigen were performed after absorption of the CSF samples with Protein A-containing Staphylococcus aureus and treatment with 2-mercaptoethanol. The results point to different pathological significances of the precipitation line anomalies revealed by RIE, that might be relevant for some of the patients investigated.

摘要

采用火箭免疫电泳(RIE)法,以抗人IgG血清对50例亚急性硬化性全脑炎(SSPE)患者的未浓缩脑脊液(CSF)样本进行检测。观察到两种免疫沉淀模式:仅向阴极延伸的沉淀和呈双极延伸的沉淀。在用含蛋白A的金黄色葡萄球菌吸附脑脊液样本并经2-巯基乙醇处理后,进行针对麻疹病毒抗原的血凝抑制试验。结果表明,RIE显示的沉淀线异常具有不同的病理意义,这可能与部分受调查患者有关。

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