Anghileri L J, Crone-Escanye M C, Robert J
Biophysics Laboratory, Faculty of Medicine, University of Nancy, France.
Anticancer Res. 1987 Nov-Dec;7(6):1205-7.
Using the vital dye inclusion method and the radioisotopic study of Ca2+-transport, we have investigated the involvement of the gallium and lanthanum plasma-membrane interaction in the cytotoxic and antitumor characteristics of both cations. The experimental results support the hypothesis that such an interaction is the principal cause of antitumor activity, either through structural changes of the cell membrane or through inhibition of the ATPase pumps.
运用活性染料摄入法以及钙离子转运的放射性同位素研究，我们探究了镓和镧与质膜的相互作用在这两种阳离子的细胞毒性和抗肿瘤特性中的作用。实验结果支持了这样一种假说，即这种相互作用是抗肿瘤活性的主要原因，其作用机制要么是通过细胞膜的结构变化，要么是通过抑制ATP酶泵。
