镧掺杂增强氧化锌量子点的荧光及抗肿瘤效果
Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping.
作者信息
Hao Ruixin, Luo Shanshan, Wang Feiyan, Pan Xinyu, Yao Jing, Wu Jielian, Fang Haihong, Li Wenkui
机构信息
Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, Jiangxi Science and Technology Normal University, Nanchang, China.
Jiangxi Provincial Key Laboratory of Surface Engineering, Jiangxi Science and Technology Normal University, Nanchang, China.
出版信息
Front Chem. 2022 Oct 10;10:1042038. doi: 10.3389/fchem.2022.1042038. eCollection 2022.
ZnO quantum dots (QDs) have received much attention as biomarkers and drug delivery systems in cancer treatment, due to their low cost, ease of preparation, and pH-responsive degradation. However, its applications are limited by the low quantum yield and light absorption. In this work, a lanthanum-doped zinc oxide (La-ZnO) QDs-based drug delivery platform was constructed. The results show that 4% La doping is the most beneficial for improving the fluorescent properties of the ZnO QDs. After loading the drug, the cell activity was 15% at ZnO@DOX and 12% at La-ZnO@DOX. According to and experiment results, the La-ZnO QDs show enhancement of the antitumor effect. Dual enhancement of fluorescence and anti-tumor effects make La-ZnO QDs promising as a drug delivery system in cancer treatment.
氧化锌量子点（QDs）因其成本低、易于制备以及pH响应降解等特性，在癌症治疗中作为生物标志物和药物递送系统受到了广泛关注。然而，其应用受到低量子产率和光吸收的限制。在这项工作中，构建了一种基于镧掺杂氧化锌（La-ZnO）量子点的药物递送平台。结果表明，4%的镧掺杂最有利于改善氧化锌量子点的荧光特性。加载药物后，ZnO@DOX组的细胞活性为15%，La-ZnO@DOX组为12%。根据[具体实验]和实验结果，La-ZnO量子点显示出抗肿瘤效果的增强。荧光和抗肿瘤效果的双重增强使得La-ZnO量子点有望成为癌症治疗中的一种药物递送系统。
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