止血系统中的 microRNAs：不仅仅是血栓栓塞性疾病的见证者？
microRNAs in the haemostatic system: More than witnesses of thromboembolic diseases?
机构信息
Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain.
Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca, Murcia, Spain; Red CIBERER CB15/00055, Murcia, Spain.
出版信息
Thromb Res. 2018 Jun;166:1-9. doi: 10.1016/j.thromres.2018.03.021. Epub 2018 Apr 6.
MicroRNAs (miRNAs) are small endogenous RNAs that post-transcriptionally regulate gene expression. In the last few years, these molecules have been implicated in the regulation of haemostasis, and an increasing number of studies have investigated their relationship with the development of thrombosis. In this review, we discuss the latest developments regarding the role of miRNAs in the regulation of platelet function and secondary haemostasis. We also discuss the genetic and environmental factors that regulate miRNAs. Finally, we address the potential use of miRNAs as prognostic and diagnostic tools in thrombosis.
MicroRNAs (miRNAs) 是小的内源性 RNA，可以在后转录水平上调节基因表达。在过去的几年中，这些分子已被牵涉到止血的调节中，并且越来越多的研究调查了它们与血栓形成发展的关系。在这篇综述中，我们讨论了 miRNA 在调节血小板功能和二次止血中的作用的最新进展。我们还讨论了调节 miRNA 的遗传和环境因素。最后，我们探讨了 miRNA 作为血栓形成的预后和诊断工具的潜在用途。
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