Master's Degree in Pediatrics and Sciences Applied to Pediatrics, Federal University of São Paulo/São Paulo School of Medicine, São Paulo, Brazil.
Associate Professor of the Department of Pediatrics, Federal University of São Paulo/São Paulo School of Medicine and Assistant Professor of the Department of Pediatrics, ABC Medicine Faculty, São Paulo, Brazil.
Ann Nutr Metab. 2018;72(4):272-278. doi: 10.1159/000488595. Epub 2018 Apr 12.
BACKGROUND/AIMS: This study aimed to identify a possible association among high birth weight with overweight/obesity, high arterial blood pressure, dyslipidemia, and insulin resistance in children and adolescents.
This is a cross-sectional study with 719 children and adolescents (6-12 years) stratified according to birth weight (low birth weight [LBW] <2,500 g, adequate birth weight [ABW] 2,500-3,999 g, and high birth weight [HBW] ≥4,000 g). Data collected were anthropometric data, arterial blood pressure levels, lipid profile, and insulin resistance (fasting glucose and insulin, used to calculate homeostatic model assessment-IR).
The mean age of schoolchildren was 9.5 ± 2.0 years and 371 (51.6%) were male. LBW and HBW were observed in 79 of 719 (10.9%) and 40 of 719 (55.6%) children/adolescents, respectively. There was no increased risk of overweight (OR 0.9; 95% CI 0.4-2.1; p = 0.964) and obesity (OR 1.4; 95% CI 0.6-3.5; p = 0.588) in HBW group compared to LBW and ABW groups. HBW was not associated with high blood pressure, dyslipidemia, and insulin resistance. The LBW group was independently associated with higher values of systolic (OR 1.07; 95% CI 1.05-1.10; p < 0.01) and diastolic blood pressure (OR 1.04; 95% CI 1.00-1.07; p = 0.044).
There was no association between HBW with overweight/obesity and classic cardiovascular risk factors in this group of children/adolescents. Only LBW was related to higher blood pressure levels.
背景/目的：本研究旨在确定高出生体重与超重/肥胖、高动脉血压、血脂异常和儿童及青少年胰岛素抵抗之间可能存在的关联。
这是一项横断面研究，纳入了 719 名儿童及青少年（6-12 岁），根据出生体重进行分层（低出生体重 [LBW] <2500g、适当出生体重 [ABW] 2500-3999g 和高出生体重 [HBW] ≥4000g）。收集的数据包括人体测量数据、动脉血压水平、血脂谱和胰岛素抵抗（空腹血糖和胰岛素，用于计算稳态模型评估-IR）。
儿童的平均年龄为 9.5±2.0 岁，其中 371 名（51.6%）为男性。LBW 和 HBW 分别见于 719 名儿童及青少年中的 79 名（10.9%）和 40 名（55.6%）。与 LBW 和 ABW 组相比，HBW 组超重（OR 0.9；95%CI 0.4-2.1；p=0.964）和肥胖（OR 1.4；95%CI 0.6-3.5；p=0.588）的风险无增加。HBW 与高血压、血脂异常和胰岛素抵抗无关。LBW 组与较高的收缩压（OR 1.07；95%CI 1.05-1.10；p<0.01）和舒张压（OR 1.04；95%CI 1.00-1.07；p=0.044）独立相关。
在该组儿童及青少年中，HBW 与超重/肥胖及经典心血管危险因素之间无关联。仅 LBW 与更高的血压水平相关。
