Sasani Maryam, Nabavi Reza, Hajinezhad Mohammadreza, Hasanein Parisa
Department of Pathobiology Veterinary Science, Faculty of Veterinary Medicine, School of Basic Sciences, University of Zabol, Zabol 98613635856, Iran.
Department of Basic Veterinary Science, Faculty of Veterinary Medicine, School of Basic Sciences, University of Zabol, Zabol 98613635856, Iran.
J Vet Sci. 2018 Jul 31;19(4):500-504. doi: 10.4142/jvs.2018.19.4.500.
We studied the toxic effects of a cyst extract fed to mice. Degenerative changes were found in mice gavage-fed fresh, frozen, and heat-treated cyst extract. There were increases in the levels of serum aspartate aminotransferase and alanine aminotransferase as well as hepatic and brain malondialdehyde (MDA) levels along with concomitant decreases in catalase (CAT) and superoxide dismutase (SOD) activities of mice receiving fresh and frozen extracts. Gavage feeding of heat-treated cyst extract had no effects on liver enzymes or brain MDA content, but the liver MDA level did increase. Mice in the heat-treated cyst group showed reduced CAT and SOD activities as well as increased hepatic MDA levels compared to those in the control group. These results indicate that an extract of cyst can induce oxidative stress and hepatic injury, even after heat treatment.
我们研究了喂食小鼠囊肿提取物的毒性作用。在经灌胃给予新鲜、冷冻和热处理囊肿提取物的小鼠中发现了退行性变化。接受新鲜和冷冻提取物的小鼠血清天冬氨酸转氨酶和丙氨酸转氨酶水平以及肝脏和脑丙二醛（MDA）水平升高，同时过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性降低。灌胃给予热处理囊肿提取物对肝脏酶或脑MDA含量无影响，但肝脏MDA水平确实升高。与对照组相比，热处理囊肿组的小鼠CAT和SOD活性降低，肝脏MDA水平升高。这些结果表明，即使经过热处理，囊肿提取物仍可诱导氧化应激和肝损伤。
