Kalra L, Bone M F
Department of Chest Medicine, Russells Hall Hospital, Dudley, West Midlands, England.
Chest. 1988 Apr;93(4):739-41. doi: 10.1378/chest.93.4.739.
A controlled double-blind crossover study of ocular complications associated with nebulized ipratropium bromide and salbutamol therapy for respiratory distress was undertaken in 46 chronic bronchitis patients. There was no significant rise in intraocular pressure or change in anterior chamber angle in patients with open-angle glaucoma, narrow-angle glaucoma or control subjects following treatment with either drug. However, when the two drugs were used in combination, intraocular pressure rose in patients with narrow-angle glaucoma but not in patients with open-angle glaucoma or in control subjects. Transient angle closure was seen in five of these patients. Intraocular pressures did not rise when swimming goggles were used to protect the eyes or when antiglaucoma treatment was continued. Nebulized bronchodilator therapy is safe in nonglaucomatous patients and those with open-angle glaucoma. Ocular complications can follow combined ipratropium bromide and salbutamol nebulization in patients with narrow-angle glaucoma, but can be prevented by using the drugs separately, protecting the eyes and ensuring continued antiglaucoma measures.
对46例慢性支气管炎患者进行了一项关于雾化吸入异丙托溴铵和沙丁胺醇治疗呼吸窘迫相关眼部并发症的对照双盲交叉研究。使用这两种药物治疗后，开角型青光眼、闭角型青光眼患者或对照组患者的眼压均未显著升高，前房角也未发生变化。然而，当两种药物联合使用时，闭角型青光眼患者的眼压升高，而开角型青光眼患者或对照组患者的眼压未升高。其中5例患者出现了短暂性房角关闭。使用游泳镜保护眼睛或继续进行抗青光眼治疗时，眼压并未升高。雾化支气管扩张剂治疗对非青光眼患者和开角型青光眼患者是安全的。闭角型青光眼患者联合雾化吸入异丙托溴铵和沙丁胺醇可能会出现眼部并发症，但可通过分别使用药物、保护眼睛和确保持续的抗青光眼措施来预防。
