异丙托溴铵气雾剂与沙丁胺醇在慢性支气管炎和哮喘中的比较
Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma.
作者信息
Petrie G R, Palmer K N
出版信息
Br Med J. 1975 Feb 22;1(5955):430-2. doi: 10.1136/bmj.1.5955.430.
Abstract
The effects of inhaling 200 mu g of salbutamol were compared with those of inhaling 40 mu g of ipratropium bromide singly and in combination with salbutamol in eight patients with bronchitis and eight asthmatic patients in a double-blind controlled trial. Changes in airways resistance were assessed by measuring the forced expiratory volume in 1 second and specific airways conductance. Both drugs were significantly better in relieving airways obstruction than placebo. Salbutamol was significantly more effective than ipratropium bromide in patients with asthma, but in the patients with bronchitis there was no significant difference between salbutamol and ipratropium bromide. The combination of the two drugs produced a slightly greater and longer response than either drug alone but this was not significant.
摘要
在一项双盲对照试验中，对8名支气管炎患者和8名哮喘患者吸入200μg沙丁胺醇的效果与单独吸入40μg异丙托溴铵以及与沙丁胺醇联合吸入的效果进行了比较。通过测量1秒用力呼气量和比气道传导率来评估气道阻力的变化。两种药物在缓解气道阻塞方面均明显优于安慰剂。在哮喘患者中，沙丁胺醇比异丙托溴铵显著更有效，但在支气管炎患者中，沙丁胺醇和异丙托溴铵之间没有显著差异。两种药物联合使用产生的反应比单独使用任何一种药物都略大且持续时间更长，但不显著。
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