Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Semin Arthritis Rheum. 2019 Feb;48(4):644-648. doi: 10.1016/j.semarthrit.2018.03.009. Epub 2018 Mar 17.
This study aims to evaluate whether serum Bisphenol A (BPA) is a risk factor for hyperuricemia.
In this prospective study, a total of 482 participants without hyperuricemia were enrolled at baseline and followed up for 6 years. Clinical characteristics were recorded, and serum levels of uric acid and BPA were measured. Participants were stratified into tertiles according to low, median, and high baseline serum BPA levels. Regression models were used to analyze associations of serum BPA with the change in uric acid and the risk of developing hyperuricemia.
At baseline, serum concentrations of BPA was 0.51 (0.24-2.37) ng/mL. After 6 years of follow-up, the change in serum uric acid concentration from baseline to the 6-year mark was significantly higher in subjects with higher baseline BPA concentration (0.03 ± 0.19, 0.07 ± 0.21, and 0.11 ± 0.25mg/dL for low, median, and high tertiles, respectively, P = 0.006). When adjusted for potential confounders, such as age, renal function, and history of diabetes and hypertension, multivariable logistic analyses showed that subjects in the median or high baseline BPA tertiles exhibited a twofold higher risk of 6-year hyperuricemia incidence compared to subjects in the low baseline BPA tertile [odds ratio (OR) = 2.28 (95% CI: 1.05-4.95) for the median tertile; 2.42 (1.07-5.48) for the high tertile, P = 0.043].
In conclusion, serum BPA is an independent risk factor for hyperuricemia.
本研究旨在评估血清双酚 A（BPA）是否是高尿酸血症的危险因素。
在这项前瞻性研究中，共纳入了 482 名基线时无高尿酸血症的参与者，并进行了 6 年的随访。记录了临床特征，并测量了血尿酸和 BPA 的血清水平。根据低、中、高基线血清 BPA 水平将参与者分层为三个三分位组。回归模型用于分析血清 BPA 与尿酸变化和发生高尿酸血症风险之间的关联。
基线时，血清 BPA 浓度为 0.51（0.24-2.37）ng/mL。在 6 年的随访后，与基线相比，基线时 BPA 浓度较高的受试者血清尿酸浓度的变化在 6 年时显著更高（低、中、高三分位组分别为 0.03±0.19、0.07±0.21 和 0.11±0.25mg/dL，P=0.006）。在校正了年龄、肾功能以及糖尿病和高血压病史等潜在混杂因素后，多变量逻辑分析显示，与低基线 BPA 三分位组相比，中值或高基线 BPA 三分位组的受试者在 6 年内发生高尿酸血症的风险增加了两倍[中值三分位组的比值比（OR）=2.28（95%CI：1.05-4.95）；高三分位组的比值比（OR）=2.42（1.07-5.48），P=0.043]。
综上所述，血清 BPA 是高尿酸血症的一个独立危险因素。
