高甘油三酯血症和高尿酸血症：城市居民的回顾性研究。
Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.
机构信息
Laboratory Medicine Center, Lanzhou University Second Hospital, No. 82 Cuiyingmen Lanzhou, Lanzhou, 730030, Gansu, China.
Department of Clinical Laboratory, The First People's Hospital of Baiyin, Baiyin, 730900, Gansu, China.
出版信息
Lipids Health Dis. 2019 Apr 1;18(1):81. doi: 10.1186/s12944-019-1031-6.
BACKGROUND
The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).
METHODS
The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. The risk of hyperuricemia was assessed in four Quartiles (Q1 to Q4) according to TG levels using multivariate-adjusted logistic regression models.
RESULTS
The total incidence rate of HUA was 62.3/1000 person-years. In the univariate analysis, the risk of hyperuricemia in people with hypertriglyceridemia was 2.353 times that of normal triglycerides, with a 95% confidence interval of (2.011, 2.754), and the risk of hyperuricemia in men was 1.86 times of female, and the 95% confidence interval is (1.634, 2.177). After adjusting the potential confounders, the relative risk RR of TG at Q2 Q3 Q4 was 1.445 (95%CI:1.114, 1.901), 2.075 (1.611, 2.674), 2.972 (2.322, 3.804).
CONCLUSIONS
TG is an independent risk factor for hyperuricemia. As the level of TG increases, the risk of HUA increases.
背景
本研究旨在探讨高甘油三酯血症与高尿酸血症（HUA）之间的关系。
方法
该研究纳入了 3884 名未接受药物治疗的受试者作为基线人群。每位参与者在 2011 年至 2017 年间至少接受了三次年度健康检查。采用多变量调整的逻辑回归模型，根据 TG 水平将研究对象分为四个四分位（Q1 到 Q4），评估发生高尿酸血症的风险。
结果
HUA 的总发生率为 62.3/1000 人年。单因素分析显示，高甘油三酯血症患者发生高尿酸血症的风险是非高甘油三酯血症患者的 2.353 倍，95%可信区间为（2.011，2.754），男性发生高尿酸血症的风险是女性的 1.86 倍，95%可信区间为（1.634，2.177）。调整潜在混杂因素后，TG 在 Q2、Q3、Q4 四分位的相对风险 RR 分别为 1.445（95%CI：1.114，1.901）、2.075（1.611，2.674）、2.972（2.322，3.804）。
结论
TG 是高尿酸血症的独立危险因素。随着 TG 水平的升高，HUA 的发病风险增加。
Zotero 插件