Bhuyan Biman, Baishya Krishna, Rajak Prakash
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.
Indian J Clin Biochem. 2018 Apr;33(2):190-195. doi: 10.1007/s12291-017-0666-1. Epub 2017 May 18.
commonly known as 'sessile joy weed' or 'dwarf copperleaf' is found throughout the hotter parts of India up to an altitude of 1200 m. In Assam, the plant has been traditionally used in the treatment of jaundice along with other ailments. The study focuses primarily on the evaluation of hepatoprotective activity of the plant with special references to its putative protective role in carbon tetrachloride induced liver injury on Wister albino rat. The in vivo hepatoprotective activity of the methanolic extract at the dose of 250 mg/kg body weight was highly effective in controlling SGPT, SGOT, ALP, serum cholesterol and serum bilirubin level as compared to silymarin. The said extract also significantly lowered the lipid profile caused by CCl. The activity shown by methanolic extract of the whole plant of is of considered importance and thus justified its use in controlling hepatic diseases in traditional treatment system.
通常被称为“无柄喜旱莲子草”或“矮叶铁苋菜”，在印度较炎热地区直至海拔1200米处均有发现。在阿萨姆邦，该植物传统上一直与其他疾病一起用于治疗黄疸。本研究主要侧重于评估该植物的肝保护活性，特别提及它对四氯化碳诱导的Wistar白化大鼠肝损伤的假定保护作用。与水飞蓟宾相比，250毫克/千克体重剂量的甲醇提取物的体内肝保护活性在控制谷丙转氨酶、谷草转氨酶、碱性磷酸酶、血清胆固醇和血清胆红素水平方面非常有效。上述提取物还显著降低了由四氯化碳引起的脂质谱。该植物全株甲醇提取物所显示的活性具有重要意义，因此证明了其在传统治疗体系中用于控制肝脏疾病的合理性。
