King Saud Bin Abdulaziz University for Health Sciences, King Fahad Medical City, Riyadh, Saudi Arabia.
Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):111-4. doi: 10.1111/j.1742-7843.2011.00692.x. Epub 2011 Mar 28.
Cytochrome P450 (CYP) 2C9 is responsible for the metabolism of a number of widely used drugs such as oral anticoagulants, oral antidiabetics and non-steroidal anti-inflammatory drugs. The CYP2C9 is a genetically polymorphic enzyme. The most common allele is CYP2C91, while CYP2C92 and CYP2C9*3 are the less-frequent variants. The activity of the enzyme encoded by either CYP2C9 *2 or 3 variant is lower compared with that of the CYP2C91. The metabolism of most of the CYP2C9 substrates decreases in varying degrees in subjects carrying the CYP2C9 *2 or *3 allele. The aim of this study was to investigate the frequencies of the major variants of the CYP2C9 in Saudi Arabians.
细胞色素 P450（CYP）2C9 负责代谢许多广泛使用的药物，如口服抗凝剂、口服抗糖尿病药和非甾体抗炎药。CYP2C9 是一种遗传多态性酶。最常见的等位基因是 CYP2C91，而 CYP2C92 和 CYP2C93 是较少见的变体。由 CYP2C92 或3 变体编码的酶的活性与 CYP2C91 相比较低。携带 CYP2C92 或3 等位基因的受试者中，大多数 CYP2C9 底物的代谢程度不同程度降低。本研究旨在调查沙特阿拉伯人中 CYP2C9 的主要变体的频率。
